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Problems associated with biological markers of Alzheimer's disease

被引：28
作者：
Frey, HJ
Mattila, KM
Korolainen, MA
Pirttilä, T
机构：
[1] Univ Tampere, Sch Med, Brain Res Ctr, FIN-33014 Tampere, Finland
[2] Univ Kuopio, Dept Neurol, Kuopio, Finland
[3] Kuopio Univ Hosp, SF-70210 Kuopio, Finland
[4] Tampere Univ Hosp, Ctr Lab Med, Tampere, Finland
来源：
NEUROCHEMICAL RESEARCH | 2005年 / 30卷 / 12期
关键词：
Alzheimer's disease; biological markers; cerebrospinal fluid; proteomics; proteins; immunology; genetics; imaging; blood;
D O I：
10.1007/s11064-005-8827-7
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 [生物化学与分子生物学]; 081704 [应用化学];
摘要：
The etiopathogenesis of Alzheimer's disease (AD) is still unclear, although clinical diagnostic criteria exist and the neuropathology of AD has been studied in great detail during the last 20 years. The present study addresses certain problems in the search for biological markers for the diagnosis, as well as in the follow-up of the course of AD and its differential diagnosis and reports some of our own observations in comparison with other studies. These include protein, genetic and neuroimaging markers. The definitions of biological markers and search strategies are also discussed.
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收藏
页码：1501 / 1510
页数：10
相关论文
共 104 条
[1]
IMMUNOCHEMICAL IDENTIFICATION OF THE SERINE PROTEASE INHIBITOR ALPHA-1-ANTICHYMOTRYPSIN IN THE BRAIN AMYLOID DEPOSITS OF ALZHEIMERS-DISEASE [J].
ABRAHAM, CR ;
SELKOE, DJ ;
POTTER, H .
CELL, 1988, 52 (04) :487-501
[2]
ISOELECTRIC-FOCUSING AND TWO-DIMENSIONAL GEL-ELECTROPHORESIS IN PLASMA AND CEREBROSPINAL-FLUID FROM PATIENTS WITH DEMENTIA [J].
ALAFUZOFF, I ;
ADOLFSSON, R ;
BUCHT, G ;
JELLUM, E ;
MEHTA, PD ;
WINBLAD, B .
EUROPEAN NEUROLOGY, 1986, 25 (04) :285-289
[3]
The use of proteomics for the assessment of clinical samples in research [J].
Aldred, S ;
Grant, MM ;
Griffiths, HR .
CLINICAL BIOCHEMISTRY, 2004, 37 (11) :943-952
[4]
Alzheimer A., 1907, ALLG Z PSYCHIAT, V64, P146, DOI DOI 10.1002/CA.980080612
[5]
Cerebrospinal fluid tau and Aβ42 as predictors of development of Alzheimer's disease in patients with mild cognitive impairment [J].
Andreasen, N ;
Minthon, L ;
Vanmechelen, E ;
Vanderstichele, H ;
Davidsson, P ;
Winblad, B ;
Blennow, K .
NEUROSCIENCE LETTERS, 1999, 273 (01) :5-8
[6]
Bales K R, 2002, Mol Interv, V2, P363, DOI 10.1124/mi.2.6.363
[7]
Consensus recommendations for the postmortem diagnosis of Alzheimer's disease [J].
Ball, M ;
Braak, H ;
Coleman, P ;
Dickson, D ;
Duyckaerts, C ;
Gambetti, P ;
Hansen, L ;
Hyman, B ;
Jellinger, K ;
Markesbery, W ;
Perl, D ;
Powers, J ;
Price, J ;
Trojanowski, JQ ;
Wisniewski, H ;
Phelps, C ;
Khachaturian, Z .
NEUROBIOLOGY OF AGING, 1997, 18 (04) :S1-S2
[8]
ISOELECTRIC-FOCUSING IN IMMOBILIZED PH GRADIENTS - PRINCIPLE, METHODOLOGY AND SOME APPLICATIONS [J].
BJELLQVIST, B ;
EK, K ;
RIGHETTI, PG ;
GIANAZZA, E ;
GORG, A ;
WESTERMEIER, R ;
POSTEL, W .
JOURNAL OF BIOCHEMICAL AND BIOPHYSICAL METHODS, 1982, 6 (04) :317-339
[9]
ALZHEIMERS-DISEASE - A METABOLIC SYSTEMS DEGENERATION [J].
BLASS, JP ;
ZEMCOV, A .
NEUROCHEMICAL PATHOLOGY, 1984, 2 (02) :103-114
[10]
CSF markers for incipient Alzheimer's disease [J].
Blennow, K ;
Hampel, H .
LANCET NEUROLOGY, 2003, 2 (10) :605-613
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