Ultrabright Organic Dots with Aggregation-Induced Emission Characteristics for Real-Time Two-Photon Intravital Vasculature Imaging

被引：375

作者：

Ding, Dan ^{[1
]}

Goh, Chi Ching ^{[2
]}

Feng, Guangxue ^{[1
]}

Zhao, Zujin ^{[3
,4
]}

Liu, Jie ^{[1
]}

Liu, Rongrong ^{[5
]}

Tomczak, Nikodem ^{[5
]}

Geng, Junlong ^{[1
]}

Tang, Ben Zhong ^{[3
,4
]}

Ng, Lai Guan ^{[2
]}

Liu, Bin ^{[1
,5
]}

机构：

[1] Natl Univ Singapore, Dept Chem & Biomol Engn, Singapore 117576, Singapore

[2] ASTAR, Singapore Immunol Network SIgN, Biopolis 138648, Singapore

[3] Hong Kong Univ Sci & Technol, Dept Chem, Kowloon, Hong Kong, Peoples R China

[4] Hong Kong Univ Sci & Technol, Div Biomed Engn, Kowloon, Hong Kong, Peoples R China

[5] Inst Mat Res Engn, Singapore 117602, Singapore

来源：

ADVANCED MATERIALS | 2013年 / 25卷 / 42期

基金：

新加坡国家研究基金会;

关键词：

aggregation-induced emission; two-photon fluorescence imaging; blood vascular imaging; nanoparticles; quantum dots; IN-VIVO; QUANTUM DOTS; NANOPARTICLES; FLUORESCENCE; ABSORPTION; TETRAPHENYLETHENE; CHROMOPHORES; MICROSCOPY; REVEALS; BEARING;

D O I：

10.1002/adma.201301938

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Ultrabright organic dots with aggregation-induced emission characteristics (AIE dots) are prepared and shown to exhibit a high quantum yield, a, large two-photon absorption cross-section, and low in vivo toxicity. Real-time two-photon intravital blood vascular imaging in various tissues substantiates that the AIE dots are effective probes for in vivo vasculature imaging in a deep and high-contrast manner. © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：6083 / 6088

页数：6

共 36 条

[1]

Intravital microscopy at the single vessel level brings new insights of vascular modification mechanisms induced by electropermeabilization [J].

Bellard, Elisabeth ;

Markelc, Bostjan ;

Pelofy, Sandrine ;

Le Guerroue, Francois ;

Sersa, Gregor ;

Teissie, Justin ;

Cemazar, Maja ;

Golzio, Muriel .

JOURNAL OF CONTROLLED RELEASE, 2012, 163 (03) :396-403

[2]

Bunau G. V., 1970, JB BIRKSPHOTOPHYSICS, V74, P1294

[3]

Lectin intravital perfusion studies in tumor-bearing mice: Micrometer-resolution, wide-area mapping of microvascular labeling, distinguishing efficiently and inefficiently perfused microregions in the tumor [J].

Debbage, PL ;

Griebel, J ;

Ried, M ;

Gneiting, T ;

DeVries, A ;

Hutzler, P .

JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY, 1998, 46 (05) :627-639

[4]

In vivo near-infrared fluorescence imaging [J].

Frangioni, JV .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2003, 7 (05) :626-634

[5]

In vivo cancer targeting and imaging with semiconductor quantum dots [J].

Gao, XH ;

Cui, YY ;

Levenson, RM ;

Chung, LWK ;

Nie, SM .

NATURE BIOTECHNOLOGY, 2004, 22 (08) :969-976

[6]

Dynamic imaging of the immune system: progress, pitfalls and promise [J].

Germain, Ronald N. ;

Miller, Mark J. ;

Dustin, Michael L. ;

Nussenzweig, Michel C. .

NATURE REVIEWS IMMUNOLOGY, 2006, 6 (07) :497-507

[7]

Multiphoton absorbing materials: Molecular designs, characterizations, and applications [J].

He, Guang S. ;

Tan, Loon-Seng ;

Zheng, Qingdong ;

Prasad, Paras N. .

CHEMICAL REVIEWS, 2008, 108 (04) :1245-1330

[8]

Deep tissue two-photon microscopy [J].

Helmchen, F ;

Denk, W .

NATURE METHODS, 2005, 2 (12) :932-940

[9]

Aggregation-induced emission [J].

Hong, Yuning ;

Lam, Jacky W. Y. ;

Tang, Ben Zhong .

CHEMICAL SOCIETY REVIEWS, 2011, 40 (11) :5361-5388

[10]

Aggregation-induced emission: phenomenon, mechanism and applications [J].

Hong, Yuning ;

Lam, Jacky W. Y. ;

Tang, Ben Zhong .

CHEMICAL COMMUNICATIONS, 2009, (29) :4332-4353

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