The search for ESR1 mutations in breast cancer

被引：64

作者：

Oesterreich, Steffi ^{[1
,2
,3
,4
]}

Davidson, Nancy E. ^{[1
,2
,3
,4
]}

机构：

[1] Univ Pittsburgh, Dept Pharmacol & Chem Biol, Womens Canc Res Ctr, Inst Canc, Pittsburgh, PA 15260 USA

[2] Univ Pittsburgh, Dept Med, Womens Canc Res Ctr, Inst Canc, Pittsburgh, PA USA

[3] UPMC Canc Ctr, Pittsburgh, PA USA

[4] Magee Womens Res Inst, Pittsburgh, PA USA

来源：

NATURE GENETICS | 2013年 / 45卷 / 12期

关键词：

HUMAN ESTROGEN-RECEPTOR; TRANSCRIPTIONAL ACTIVITY; PHOSPHORYLATION; IDENTIFICATION; ACTIVATION;

D O I：

10.1038/ng.2831

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Two new studies report the identification of activating ESR1 gene mutations in aromatase inhibitor-resistant metastatic breast cancers. This insight into therapeutic resistance suggests new approaches that may be useful in the management of endocrine-resistant breast cancer.

引用

页码：1415 / 1416

页数：2

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