The role of insulin-like growth factor I and its receptor in cell growth, transformation, apoptosis, and chemoresistance in solid tumors

被引：69

作者：

Grothey, A ^{[1
]}

Voigt, W ^{[1
]}

Schöber, C ^{[1
]}

Müller, T ^{[1
]}

Dempke, W ^{[1
]}

Schmoll, HJ ^{[1
]}

机构：

[1] Univ Halle Wittenberg, Hamatol Onkol Abt, D-06120 Halle, Germany

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 1999年 / 125卷 / 3-4期

关键词：

IGF; apoptosis; transformation chemosensitivity; signaling;

D O I：

10.1007/s004320050259

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Insulin-like growth factor I(IGF-I) exerts pleiotropic effects on mammalian cells via stimulation of its receptor (IGF-IR), a receptor tyrosine kinase. In vivo, IGF-I acts both as a local tissue growth factor and as a circulating hormone. In oncological research, IGF-I has received increased attention as the activated IGF-I/IGF-IR system displays mitogeneic, transforming, and antiapoptotic properties in various cell types by stimulating distinct intracellular signaling pathways. Recent data suggest that the anti-apoptotic effect of IGF-I may mediate decreased sensitivity to chemotherapeutic drugs in vitro and in vivo. Thus, targeting the IGF-I/IGF-IR system could serve as an approach to overcome clinical drug resistance in certain tumors.

引用

页码：166 / 173

页数：8

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