Amino-substituted thalidoimide analogs:: Potent inhibitors of TNF-α production

被引：298

作者：

Muller, GW

Chen, R

Huang, SY

Corral, LG

Wong, LM

Patterson, RT

Chen, YX

Kaplan, G

Stirling, DI

机构：

[1] Celgene Corp, Warren, NJ 07059 USA

[2] Rockefeller Univ, New York, NY 10021 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 11期

关键词：

D O I：

10.1016/S0960-894X(99)00250-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Thalidomide, (1), is a known inhibitor of TNF-alpha release in LPS stimulated human PBMC. Herein we describe the TNF-alpha inhibitory activity of amino substituted analogs of thalidomide (1) and its isoindolin-1-one analog, EM-12 (2). The 4-amino substituted analogs were found to be potent inhibitors of TNF-alpha release in LPS stimulated human PBMC. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1625 / 1630

页数：6

共 23 条

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