PTH/PTHrP receptor in early development and Indian hedgehog-regulated bone growth

被引：998

作者：

Lanske, B

Karaplis, AC

Lee, K

Luz, A

Vortkamp, A

Pirro, A

Karperien, M

Defize, LHK

Ho, C

Mulligan, RC

AbouSamra, AB

Juppner, H

Segre, GV

Kronenberg, HM

机构：

[1] MASSACHUSETTS GEN HOSP,ENDOCRINE UNIT,BOSTON,MA 02114

[2] HARVARD UNIV,SCH MED,BOSTON,MA 02114

[3] MCGILL UNIV,SIR MORTIMER B DAVIS JEWISH GEN HOSP,MONTREAL,PQ H3T 1E2,CANADA

[4] GSF MUNCHEN,INST PATHOL,D-85758 MUNICH,GERMANY

[5] HARVARD UNIV,SCH MED,DEPT GENET,BOSTON,MA 02115

[6] NETHERLANDS INST DEV BIOL,HUBRECHT LAB,NL-3584 CT UTRECHT,NETHERLANDS

[7] HARVARD UNIV,SCH MED,HOWARD HUGHES MED INST,BOSTON,MA 02115

[8] WHITEHEAD INST BIOMED RES,CAMBRIDGE,MA 02142

[9] MIT,CAMBRIDGE,MA 02139

来源：

SCIENCE | 1996年 / 273卷 / 5275期

关键词：

D O I：

10.1126/science.273.5275.663

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The PTH/PTHrP receptor binds to two ligands with distinct functions: the calcium-regulating hormone, parathyroid hormone (PTH), and the paracrine factor, PTH-related protein (PTHrP). Each ligand, in turn, is likely to activate more than one receptor. The functions of the PTH/PTHrP receptor were investigated by deletion of the murine gene by homologous recombination. Most PTH/PTHrP receptor (-/-) mutant mice died in mid-gestation, a phenotype not observed in PTHrP (-/-) mice, perhaps because of the effects of maternal PTHrP. Mice that survived exhibited accelerated differentiation of chondrocytes in bone, and their bones, grown in explant culture, were resistant to the effects of PTHrP and Sonic hedgehog. These results suggest that the PTH/PTHrP receptor mediates the effects of Indian Hedgehog and PTHrP on chondrocyte differentiation.

引用

页码：663 / 666

页数：4

共 23 条

[1] EXPRESSION CLONING OF A COMMON RECEPTOR FOR PARATHYROID-HORMONE AND PARATHYROID HORMONE-RELATED PEPTIDE FROM RAT OSTEOBLAST-LIKE CELLS - A SINGLE RECEPTOR STIMULATES INTRACELLULAR ACCUMULATION OF BOTH CAMP AND INOSITOL TRISPHOSPHATES AND INCREASES INTRACELLULAR FREE CALCIUM [J].