Evaluation of HLA Polymorphisms in Relation to Schizophrenia Risk and Infectious Exposure

被引：24

作者：

Bamne, Mikhil ^{[1
]}

Wood, Joel ^{[1
]}

Chowdari, Kodavali ^{[1
]}

Watson, Annie M. ^{[1
]}

Celik, Cemil ^{[1
,3
]}

Mansour, Hader ^{[1
]}

Klei, Lambertus ^{[4
]}

Gur, Ruben C. ^{[5
,6
]}

Bradford, L. DiAnne ^{[7
]}

Calkins, Monica E. ^{[5
]}

Santos, Alberto B. ^{[8
]}

Edwards, Neil ^{[9
]}

Kwentus, Joseph ^{[10
]}

McEvoy, Joseph P. ^{[11
]}

Allen, Trina B. ^{[11
]}

Savage, Robert M. ^{[12
]}

Nasrallah, Henry A. ^{[13
]}

Gur, Raquel E. ^{[14
]}

Perry, Rodney T.

Go, Rodney C. P. ^{[15
]}

Devlin, Bernie ^{[1
,2
]}

Yolken, Robert ^{[16
]}

Nimgaonkar, Vishwajit L. ^{[1
,2
]}

机构：

[1] Univ Pittsburgh, Western Psychiat Inst & Clin, Dept Psychiat, Sch Med, Pittsburgh, PA 15213 USA

[2] Univ Pittsburgh, Dept Human Genet, Grad Sch Publ Hlth, Pittsburgh, PA 15213 USA

[3] GATA Sch Med, Dept Psychiat, Etlik, Turkey

[4] Univ Pittsburgh, Western Psychiat Inst & Clin, Med Ctr, Computat Genet Program, Pittsburgh, PA 15213 USA

[5] Univ Penn, Dept Psychiat, Neuropsychiat Sect, Philadelphia, PA 19104 USA

[6] Philadelphia Vet Affairs Med Ctr, Philadelphia, PA USA

[7] Morehouse Sch Med, Dept Psychiat, Atlanta, GA 30310 USA

[8] Med Univ S Carolina, Dept Psychiat & Behav Sci, Charleston, SC 29425 USA

[9] Univ Tennessee, Dept Psychiat, Coll Med, Memphis, TN USA

[10] Univ Mississippi, Med Ctr, Dept Psychiat & Human Behav, Jackson, MS 39216 USA

[11] Duke Univ, Med Ctr, John Umstead Hosp, Butler, NC USA

[12] Univ Alabama Birmingham, Dept Psychiat & Behav Neurobiol, Birmingham, AL 35294 USA

[13] Univ Cincinnati, Coll Med, Dept Psychiat & Neurosci, Cincinnati, OH USA

[14] Univ Penn, Dept Psychiat, Neuropsychiat Sect, Philadelphia, PA 19104 USA

[15] Univ Alabama Birmingham, Dept Epidemiol & Int Hlth, Birmingham, AL USA

[16] Johns Hopkins Univ, Med Ctr, Stanley Div Dev Neurovirol, Baltimore, MD 21218 USA

来源：

SCHIZOPHRENIA BULLETIN | 2012年 / 38卷 / 06期

关键词：

HLA; gene; HSV-1; cytomegalovirus; schizophrenia; African American; AFRICAN-AMERICANS; COMMON VARIANTS; CONFERRING RISK; EXPLORE RISKS; ASSOCIATION; ANTIBODIES; CYTOMEGALOVIRUS; IMPAIRMENT; PAARTNERS; ANCESTRY;

D O I：

10.1093/schbul/sbs087

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background: Genome-wide association studies (C WAS) implicate single nucleotide polymorphisms (SNPs) on chromosome 6p21.3-22.1, the human leukocyte antigen (HLA) region, as common risk factors for schizophrenia (SZ). Other studies implicate viral and protozoan exposure. Our study tests chromosome 6p SNPs for effects on SZ risk with and without exposure. Method: GWAS-significant SNPs and ancestry-informative marker SNPs were analyzed among African American patients with SZ (n = 604) and controls (n = 404). Exposure to herpes simplex virus, type 1 (ISV-1), cytomegalovirus (CMV), and Toxoplasma gondii (TOX) was assayed using specific antibody assays. Results: Five SNPs were nominally associated with SZ, adjusted for population admixture (P<.05, uncorrected for multiple comparisons). These SNPs were next analyzed in relation to infectious exposure. Multivariate analysis indicated significant association between rs3130297 genotype and HSV-1 exposure; the associated allele was different from the SZ risk allele. Conclusions: We propose a model for the genesis of SZ incorporating genomic variation in the HLA region and neurotropic viral exposure for testing in additional, independent African American samples.

引用

页码：1149 / 1154

页数：6

共 29 条

[1]

The influence of latent viral infection on rate of cognitive decline over 4 years [J].