A pilot study of hormone modulation as a new treatment for mania in women with bipolar affective disorder

被引：84

作者：

Kulkarni, J

Garland, KA

Scaffidi, A

Headey, B

Anderson, R

de Castella, A

Fitzgerald, P

Davis, SR

机构：

[1] Alfred Hosp, Alfred Psychiat Res Ctr, Melbourne, Vic 3004, Australia

[2] Monash Univ, Dept Psychol Med, Clayton, Vic 3168, Australia

[3] Monash Univ, CECS, Dept Med, Clayton, Vic 3168, Australia

来源：

PSYCHONEUROENDOCRINOLOGY | 2006年 / 31卷 / 04期

关键词：

mania; women; bipolar affective disorder; tamoxifen; medroxyprogesterone acetate;

D O I：

10.1016/j.psyneuen.2005.11.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We tested and compared the use of two adjunctive hormonal agents, tamoxifen and medroxyprogesterone acetate (MPA), for the treatment of acute mania or hypomania. A total of 13 women with acute Bipolar Affective Disorder in the manic or hypomanic phase were recruited from a clinical population to participate in this 28-day, three-arm, double blind, placebo-controlled study. The women who received tamoxifen exhibited significant improvement in symptoms of mania from baseline to final assessment compared with the placebo group. The MPA group improved more than the placebo group. Further exploration of tamoxifen as a useful adjunct in the treatment of acute manic symptoms in women with Bipolar Affective Disorder is warranted. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：543 / 547

页数：5

共 15 条

[1] THE CLINICIAN-ADMINISTERED RATING-SCALE FOR MANIA (CARS-M) - DEVELOPMENT, RELIABILITY, AND VALIDITY [J].