Genomic imprinting: CTCF protects the boundaries

被引：69

作者：

Lewis, A ^{[1
]}

Murrell, A ^{[1
]}

机构：

[1] Babraham Inst, Lab Dev Genet & Imprinting, Dev Genet Programme, Cambridge CB2 4AT, England

来源：

CURRENT BIOLOGY | 2004年 / 14卷 / 07期

关键词：

D O I：

10.1016/j.cub.2004.03.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DNA-binding protein CTCF, which acts as a chromatin 'insulator', regulates imprinting of the mammalian Igf2 and H19 genes in a methylation-sensitive manner. It has now been shown that CTCF is also required for protection against de novo methylation of the differentially methylated domain of H19 in the female germline.

引用

页码：R284 / R286

页数：3

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