Dendroamides, new cyclic hexapeptides from a blue-green alga. Multidrug-resistance reversing activity of dendroamide A

被引：133

作者：

Ogino, J

Moore, RE

Patterson, GML

Smith, CD

机构：

[1] UNIV HAWAII MANOA,DEPT CHEM,HONOLULU,HI 96822

[2] FOX CHASE CANC CTR,DEPT PHARMACOL,PHILADELPHIA,PA 19111

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 06期

关键词：

D O I：

10.1021/np960178s

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Dendroamide A (1), one of three new bistratamide-type cyclic hexapeptides from the terrestrial blue-green alga (cyanobacterium) Stigonema dendroideum Fremy, exhibits multidrug-resistance reversing activity. The gross structures of the three compounds, dendroamides A-C, were determined by NMR and mass spectral analyses. Their absolute stereochemistries were determined by Marfey and chiral GC/MS analyses of derivatives formed from acid hydrolysis of the intact and ozonized peptides.

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页码：581 / 586

页数：6

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