Potentiation of artemisinin activity against chloroquine-resistant Plasmodium falciparum strains by using heme models

被引：20

作者：

Benoit-Vical, F

Robert, A

Meunier, B

机构：

[1] CNRS, Chim Coordinat Lab, F-31077 Toulouse 4, France

[2] UFR Sci Pharmaceut, Lab Immunol & Parasitol, F-34060 Montpellier, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1999年 / 43卷 / 10期

关键词：

D O I：

10.1128/AAC.43.10.2555

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The influence of different metalloporphyrin derivatives on the antimalarial activity of artemisinin was studied with two chloroquine-resistant strains of Plasmodium falciparum (FcB1-Colombia and FcM29-Cameroon) cultured in human erythrocytes. This potentiation study indicates that the manganese complex of meso-tetrakis(3-sulfonatophenyl)porphyrin has a significant synergistic effect on the activity of artemisinin against both Plasmodium strains.

引用

页码：2555 / 2558

页数：4

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