Handle with care: targeting neutrophils in chronic obstructive pulmonary disease and severe asthma?

被引:28
作者
Beeh, KM [1 ]
Beier, J [1 ]
机构
[1] Insaf Resp Res Inst, D-65187 Wiesbaden, Germany
关键词
D O I
10.1111/j.1365-2222.2006.02418.x
中图分类号
R392 [医学免疫学];
学科分类号
100102 ;
摘要
Neutrophils play an important role in the pathogenesis of airway inflammation in both chronic obstructive pulmonary disease (COPD) and severe asthma. Currently available drugs have only limited effects on neutrophilic airway inflammation, particularily in COPD. Therefore, great efforts are undertaken to address neutrophilic inflammation in chronic respiratory disorders, in particular COPD. This review summarizes the rationale for anti-neutrophilic treatment in COPD and asthma and gives a critical overview of current developments in drug therapy. Moreover, unanswered questions and limitations of clinical trial design and choice of outcome parameters for proof-of-concept studies with novel anti-neutrophilic drugs are discussed as well as potential safety issues.
引用
收藏
页码:142 / 157
页数:16
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