Cyclopiazonic Acid Biosynthesis of Aspergillus flavus and Aspergillus oryzae

被引：102

作者：

Chang, Perng-Kuang ^{[1
]}

Ehrlich, Kenneth C. ^{[1
]}

Fujii, Isao ^{[2
]}

机构：

[1] USDA ARS, So Reg Res Ctr, New Orleans, LA 70124 USA

[2] Iwate Med Univ, Sch Pharm, Yahaba, Iwate 0283694, Japan

来源：

TOXINS | 2009年 / 1卷 / 02期

关键词：

Aspergillus; cyclopiazonic acid; gene cluster; non-ribosomal peptide synthase; DIMETHYLALLYL TRYPTOPHAN SYNTHASE; NON-AFLATOXIGENIC STRAINS; COVALENTLY BOUND FLAVIN; IN-VITRO PROLIFERATION; PENICILLIUM-CYCLOPIUM; SECTION FLAVI; T-2; TOXIN; SCLEROTIA PRODUCTION; GENE-CLUSTER; OCHRATOXIN-A;

D O I：

10.3390/toxins1020074

中图分类号：

TS2 [食品工业];

学科分类号：

0832 ;

摘要：

Cyclopiazonic acid (CPA) is an indole-tetramic acid neurotoxin produced by some of the same strains of A. flavus that produce aflatoxins and by some Aspergillus oryzae strains. Despite its discovery 40 years ago, few reviews of its toxicity and biosynthesis have been reported. This review examines what is currently known about the toxicity of CPA to animals and humans, both by itself or in combination with other mycotoxins. The review also discusses CPA biosynthesis and the genetic diversity of CPA production in A. flavus/oryzae populations.

引用

页码：74 / 99

页数：26

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