Nitric oxide and lipid peroxidation

被引：299

作者：

Hogg, N ^{[1
]}

Kalyanaraman, B ^{[1
]}

机构：

[1] Med Coll Wisconsin, Biophys Res Inst, Milwaukee, WI 53226 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS | 1999年 / 1411卷 / 2-3期

关键词：

D O I：

10.1016/S0005-2728(99)00027-4

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitric oxide can both promote and inhibit lipid peroxidation. By itself, nitric oxide acts as a patent inhibitor of the lipid peroxidation chain reaction by scavenging propagatory lipid peroxyl radicals. In addition, nitric oxide can also inhibit many potential initiators of lipid peroxidation, such as peroxidase enzymes. However, in the presence of superoxide, nitric oxide forms peroxynitrite, a powerful oxidant capable of initiating lipid peroxidation and oxidizing lipid soluble antioxidants. The role of nitric oxide in vascular pathology is discussed. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：378 / 384

页数：7

共 48 条

[1] INACTIVATION OF GLUTATHIONE-PEROXIDASE BY NITRIC-OXIDE - IMPLICATION FOR CYTOTOXICITY
ASAHI, M
FUJII, J
SUZUKI, K
SEO, HG
KUZUYA, T
HORI, M
TADA, M
FUJII, S
TANIGUCHI, N
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (36) : 21035 - 21039
[2] The oxidation of selenocysteine is involved in the inactivation of glutathione peroxidase by nitric oxide donor
Asahi, M
Fujii, J
Takao, T
Kuzuya, T
Hori, M
Shimonishi, Y
Taniguchi, N
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (31) : 19152 - 19157
[3] ALKYL NITRATE FORMATION FROM THE NOX-AIR PHOTOOXIDATIONS OF C2-C8 N-ALKANES
ATKINSON, R
ASCHMANN, SM
CARTER, WPL
WINER, AM
PITTS, JN
[J]. JOURNAL OF PHYSICAL CHEMISTRY, 1982, 86 (23) : 4563 - 4569
[4] APPARENT HYDROXYL RADICAL PRODUCTION BY PEROXYNITRITE - IMPLICATIONS FOR ENDOTHELIAL INJURY FROM NITRIC-OXIDE AND SUPEROXIDE
BECKMAN, JS
BECKMAN, TW
CHEN, J
MARSHALL, PA
FREEMAN, BA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1990, 87 (04) : 1620 - 1624
[5] Regression or progression - Dependency on vascular nitric oxide
Candipan, RC
Wang, BY
Buitrago, R
Tsao, PS
Cooke, JP
[J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 1996, 16 (01) : 44 - 50
[6] CHRONIC INHIBITION OF NITRIC-OXIDE PRODUCTION ACCELERATES NEOINTIMA FORMATION AND IMPAIRS ENDOTHELIAL FUNCTION IN HYPERCHOLESTEROLEMIC RABBITS
CAYATTE, AJ
PALACINO, JJ
HORTEN, K
COHEN, RA
[J]. ARTERIOSCLEROSIS AND THROMBOSIS, 1994, 14 (05): : 753 - 759
[7] FREE-RADICAL CHEMISTRY OF CIGARETTE-SMOKE AND ITS TOXICOLOGICAL IMPLICATIONS
CHURCH, DF
PRYOR, WA
[J]. ENVIRONMENTAL HEALTH PERSPECTIVES, 1985, 64 : 111 - 126
[8] COOKE JP, 1991, BASIC RES CARDIOL, V86, P173
[9] Blood radicals - Reactive nitrogen species, reactive oxygen species, transition metal ions, and the vascular system
DarleyUsmar, V
Halliwell, B
[J]. PHARMACEUTICAL RESEARCH, 1996, 13 (05) : 649 - 662
[10] THE SIMULTANEOUS GENERATION OF SUPEROXIDE AND NITRIC-OXIDE CAN INITIATE LIPID-PEROXIDATION IN HUMAN LOW-DENSITY-LIPOPROTEIN
DARLEYUSMAR, VM
HOGG, N
OLEARY, VJ
WILSON, MT
MONCADA, S
[J]. FREE RADICAL RESEARCH COMMUNICATIONS, 1992, 17 (01): : 9 - 20

← 1 2 3 4 5 →