Immunopharmacology:: anti-inflammatory therapy targeting transcription factors

被引：24

作者：

Pfeilschifter, J ^{[1
]}

Mühl, H ^{[1
]}

机构：

[1] Univ Frankfurt Klinikum, Zentrum Pharmakol, D-60590 Frankfort, Germany

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 375卷 / 1-3期

关键词：

inflammation; immunopharmacology; gene expression; transcription factor; glucocorticoid; cyclosporin A; tacrolismus; salicylate; aspirin; recombinant cytokine; gene therapy;

D O I：

10.1016/S0014-2999(99)00361-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Immunopharmacology is one of the most dynamic areas in pharmacology encompassing classical immunosuppressive drugs which reveal completely new clues concerning their mode of action as well as novel molecular biology approaches for treating inflammatory and autoimmune diseases, infections and cancer. This article focuses on transcription factors that regulate cell activities involved in immune and inflammatory cell responses and how traditional anti-inflammatory compounds such as glucocorticoids, cyclosporins, tacrolismus and salicylates interfere with the activation cascades triggering the transcription factors. Moreover, promising new initiatives for selective therapeutics including recombinant anti-inflammatory cytokines and proinflammatory cytokine antagonists, and gene therapy will be presented. (C) 1999 Elsevier Science B.V. All rights reserved.

引用

页码：237 / 245

页数：9

共 101 条

[1] p55 tumor necrosis factor receptor fusion protein in the treatment of patients with severe sepsis and septic shock - A randomized controlled multicenter trial [J].

Abraham, E ;

Glauser, MP ;

Butler, T ;

Garbino, J ;

Gelmont, D ;

Laterre, PF ;

Kudsk, K ;

Bruining, HA ;

Otto, C ;

Tobin, E ;

Zwingelstein, C ;

Lesslauer, W ;

Leighton, A .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 277 (19) :1531-1538

[2] Interleukin-1 receptor antagonist: Role in biology [J].

Arend, WP ;

Malyak, M ;

Guthridge, CJ ;

Gabay, C .

ANNUAL REVIEW OF IMMUNOLOGY, 1998, 16 :27-55

[3] IMMUNOSUPPRESSION BY GLUCOCORTICOIDS - INHIBITION OF NF-KAPPA-B ACTIVITY THROUGH INDUCTION OF I-KAPPA-B SYNTHESIS [J].

AUPHAN, N ;

DIDONATO, JA ;

ROSETTE, C ;

HELMBERG, A ;

KARIN, M .

SCIENCE, 1995, 270 (5234) :286-290

[4] Pro-inflammatory signaling:: Last pieces in the NF-κB puzzle [J].

Baeuerle, PA .

CURRENT BIOLOGY, 1998, 8 (01) :R19-R22

[5]

BAKKER A, 1997, ARTHRITIS RHEUM, V5, P893

[6] Immunopharmacology - Immunomodulation and immunotherapy [J].

Ballow, M ;

Nelson, R .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (22) :2008-2017

[7] ANTIINFLAMMATORY ACTIONS OF STEROIDS - MOLECULAR MECHANISMS [J].

BARNES, PJ ;

ADCOCK, I .

TRENDS IN PHARMACOLOGICAL SCIENCES, 1993, 14 (12) :436-441

[8] Predicting bacteremia in patients with sepsis syndrome [J].

Bates, DW ;

Sands, K ;

Miller, E ;

Lanken, PN ;

Hibberd, PL ;

Graman, PS ;

Schwartz, JS ;

Kahn, K ;

Snydman, DR ;

Parsonnet, J ;

Moore, R ;

Black, E ;

Johnson, BL ;

Jha, A ;

Platt, R .

JOURNAL OF INFECTIOUS DISEASES, 1997, 176 (06) :1538-1551

[9]

BERKMAN N, 1995, J IMMUNOL, V155, P4412

[10] Attenuation of collagen-induced arthritis in mice by treatment with vector cells engineered to secrete interleukin-13 [J].

Bessis, N ;

Boissier, MC ;

Ferrara, P ;

Blankenstein, T ;

Fradelizi, D ;

Fournier, C .

EUROPEAN JOURNAL OF IMMUNOLOGY, 1996, 26 (10) :2399-2403

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