Synthesis and applications of fluorous silyl protecting groups with improved acid stability

被引：60

作者：

Röver, S

Wipf, P ^{[1
]}

机构：

[1] Univ Pittsburgh, Dept Chem, Pittsburgh, PA 15260 USA

[2] F Hoffmann La Roche & Co Ltd, Div Pharma, Preclin Res, Nervous Syst, CH-4070 Basel, Switzerland

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 31期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0040-4039(99)01106-5

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Fluorous alkoxysilyl protecting groups have been developed and evaluated for their acid stability. tert-Butyl-phenyl-1H,1H,2H,2H-heptadecafluorodecyloxysilyl (BPFOS) ethers in particular were found to be surprisingly acid stable and allow simple protection-purification-deprotection schemes by liquid-liquid extraction with FC72/CH3CN or by solid phase extraction with fluorous reverse phase silica gel. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：5667 / 5670

页数：4

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