Mitochondrial uncoupling proteins: New insights from functional and proteomic studies

被引：20

作者：

Douette, P ^{[1
]}

Sluse, FE ^{[1
]}

机构：

[1] Lab Bioenerget, B-4000 Liege, Belgium

来源：

FREE RADICAL BIOLOGY AND MEDICINE | 2006年 / 40卷 / 07期

关键词：

uncoupling protein; mitochondria; mitoproteome; proteomics; 2D-DIGE; free radical;

D O I：

10.1016/j.freeradbiomed.2005.12.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria are the major sites of ATP synthesis through oxidative phosphorylation, a process that is weakened by proton leak. Uncoupling proteins are mitochondrial membrane proteins specialized in inducible proton conductance. They dissipate the proton electrochemical gradient established by the respiratory chain at the expense of reducing substrates. Several physiological roles have been suggested for uncoupling proteins, including roles in the control of the cellular energy balance and in preventive action against oxidative stress. This review focuses on new leads emerging from comparative proteomics about the involvement of uncoupling protein in the mitochondrial physiology. A brief overview on uncoupling proteins and on proteomics applied to mitochondria is also presented herein. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：1097 / 1107

页数：11

共 107 条

[1] A novel experimental design for comparative two-dimensional gel analysis: Two-dimensional difference gel electrophoresis incorporating a pooled internal standard [J].