Admixture as the basis for genetic mapping

被引:132
作者
Buerkle, C. Alex [1 ]
Lexer, Christian [2 ]
机构
[1] Univ Wyoming, Dept Bot, Laramie, WY 82071 USA
[2] Royal Bot Gardens, Jodrell Lab, Richmond TW9 3DS, Surrey, England
基金
英国自然环境研究理事会; 美国国家科学基金会;
关键词
D O I
10.1016/j.tree.2008.07.008
中图分类号
Q14 [生态学(生物生态学)];
学科分类号
071012 ; 0713 ;
摘要
Genetic mapping in natural populations is increasing rapidly in feasibility and accessibility. As with many areas in genetics, advances in molecular techniques and statistics are drastically altering how we can investigate inheritance in wild organisms. For ecology and evolution, this is particularly significant and promising, because many of the organisms of interest are not amenable to conventional genetic approaches. Admixture mapping falls within a family of statistical approaches that use natural recombination and linkage disequilibrium between genetic markers and phenotypes as the basis for mapping. Our aim in this review is to provide a snapshot of previous and ongoing research, existing methods and challenges, the nature of questions that can be investigated and prospects for the future of admixture mapping.
引用
收藏
页码:686 / 694
页数:9
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