Acylfulvenes, a new class of potent antitumor agents

被引：46

作者：

McMorris, TC

Kelner, MJ

Wang, W

Diaz, MA

Estes, LA

Taetle, R

机构：

[1] UNIV CALIF SAN DIEGO, DEPT PATHOL, LA JOLLA, CA 92093 USA

[2] UNIV ARIZONA, ARIZONA CANC CTR, DIV HEMATOL, TUCSON, AZ 85724 USA

来源：

EXPERIENTIA | 1996年 / 52卷 / 01期

关键词：

acylfulvene; illudin S; sesquiterpene; antitumor agents;

D O I：

10.1007/BF01922420

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Acylfulvene, derived from the sesquiterpene illudin S by treatment with acid (reverse Prins reaction), is far less reactive to thiols than illudin S. However, it is reduced readily to an aromatic product, in the same way as illudin S. This may explain its greatly improved therapeutic index compared to that of the parent compound.

引用

页码：75 / 80

页数：6

共 19 条

[1] REVERSIBLE ADDITION OF THIOLS TO STEROID ALPHA,BETA-UNSATURATED CARBONYL GROUPS - POSSIBLE ROLE IN STEROID-PROTEIN INTERACTIONS [J].