18F Labeled Nanoparticles for in Vivo PET-CT Imaging

被引：197

作者：

Devaraj, Neat K.

Keliher, Edmund J.

Thurber, Greg M.

Nahrendorf, Matthias

Weissleder, Ralph ^{[1
]}

机构：

[1] Massachusetts Gen Hosp, Ctr Syst Biol, Boston, MA 02114 USA

来源：

BIOCONJUGATE CHEMISTRY | 2009年 / 20卷 / 02期

关键词：

SUPERPARAMAGNETIC IRON-OXIDE; CYCLOADDITION; PEPTIDES;

D O I：

10.1021/bc8004649

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

We report the synthesis and in vivo characterization of an F-18 modified trimodal nanoparticle (F-18-CLIO). This particle consists of cross-linked dextran held together in core-shell formation by a superparamagnetic iron oxide core and functionalized with the radionuclide F-18 in high yield via "click" chemistry. The particle can be detected with positron emission tomography, fluorescence molecular tomography, and magnetic resonance imaging. The presence of F-18 dramatically lowers the detection threshold of the nanoparticles, while the facile conjugation chemistry provides a simple platform for rapid and efficient nanoparticle labeling.

引用

收藏

页码：397 / 401

页数：5

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