Inhibition of hepatitis B surface antigen secretion on human hepatoma cells. Components from Rubia cordifolia

被引：92

作者：

Ho, LK

Don, MJ

Chen, HC

Yeh, SF

Chen, JM

机构：

[1] NATL RES INST CHINESE MED, TAIPEI HSIEN, TAIWAN

[2] NATL YANG MING UNIV, DEPT BIOCHEM, TAIPEI, TAIWAN

[3] NATL YANG MING UNIV, GRAD INST CLIN MED, TAIPEI, TAIWAN

来源：

JOURNAL OF NATURAL PRODUCTS | 1996年 / 59卷 / 03期

关键词：

D O I：

10.1021/np960200h

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The antiviral activity in the roots of Rubia cordifolia was examined, and three naphthohydroquinones, furomollugin (1), mollugin (2), and rubilactone (3), were isolated from it. Compounds 1 and 2 strongly suppressed the secretion of hepatitis B surface antigen (HBsAg), both with IC50 = 2.0 mu g/mL, in human hepatoma Hep3B cells while having little effect on the viability of the cells, Evaluation of structurally related derivatives of 1 and 2 revealed that a 6-hydroxy group and a pyran or furan ring contribute to this suppressive effect.

引用

页码：330 / 333

页数：4

共 20 条

[1] CONTROLLED SYNTHESIS OF HBSAG IN A DIFFERENTIATED HUMAN-LIVER CARCINOMA-DERIVED CELL-LINE [J].