Lack of female bias in a mouse model of autoimmune hyperthyroidisim (Graves' disease)

被引：19

作者：

Jaume, JC ^{[1
]}

Rapoport, B ^{[1
]}

McLachlan, SM ^{[1
]}

机构：

[1] VA Med Ctr, San Francisco, CA USA

来源：

AUTOIMMUNITY | 1999年 / 29卷 / 04期

关键词：

thyroid autoimmunity; Graves' disease; TSHR autoantibodies; gender;

D O I：

10.3109/08916939908994746

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We observed no difference between males and females in terms of susceptibility to TSHR antibody induction or development of hyperthyroidism following injection of TSHR+, class II+ fibroblasts. Despite the lack of female susceptibility, the Chiba mouse model resembles other aspects of Graves disease, including the contribution of non-MHC genes and the importance of the N-terminal region of the TSHR ectodomain for TSHR antibody epitopes. Consequently, future investigations using this model are likely to provide valuable insight into the immune response to the TSHR, a major organ-specific autoantigen in humans.

引用

收藏

页码：269 / 272

页数：4

相关论文

共 13 条

[1] Evidence for negative cooperativity among human thyrotropin receptors overexpressed in mammalian cells [J].

Chazenbalk, GD ;

Kakinuma, A ;

Jaume, JC ;

McLachlan, SM ;

Rapoport, B .

ENDOCRINOLOGY, 1996, 137 (11) :4586-4591

[2] HUMAN ORGAN-SPECIFIC AUTOIMMUNE-DISEASE - MOLECULAR-CLONING AND EXPRESSION OF AN AUTOANTIBODY GENE REPERTOIRE FOR A MAJOR AUTOANTIGEN REVEALS AN ANTIGENIC IMMUNODOMINANT REGION AND RESTRICTED IMMUNOGLOBULIN GENE USAGE IN THE TARGET ORGAN [J].

CHAZENBALK, GD ;

PORTOLANO, S ;

RUSSO, D ;

HUTCHISON, JS ;

RAPOPORT, B ;

MCLACHLAN, S .

JOURNAL OF CLINICAL INVESTIGATION, 1993, 92 (01) :62-74

[3] EXON-SHUFFLING MAPS CONTROL OF ANTIBODY-RECOGNITION AND T-CELL-RECOGNITION SITES TO THE NH2-TERMINAL DOMAIN OF THE CLASS-II MAJOR HISTOCOMPATIBILITY POLYPEPTIDE-A-BETA [J].

GERMAIN, RN ;

ASHWELL, JD ;

LECHLER, RI ;

MARGULIES, DH ;

NICKERSON, KM ;

SUZUKI, G ;

TOU, JYL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1985, 82 (09) :2940-2944

[4] Thyrotropin receptor autoantibodies in serum are present at much lower levels than thyroid peroxidase autoantibodies: Analysis by flow cytometry [J].

Jaume, JC ;

Kakinuma, A ;

Chazenbalk, GD ;

Rapoport, B ;

McLachlan, SM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1997, 82 (02) :500-507

[5] Both the 5' and 3' noncoding regions of the thyrotropin receptor messenger ribonucleic acid influence the level of receptor protein expression in transfected mammalian cells [J].

Kakinuma, A ;

Chazenbalk, G ;

Filetti, S ;

McLachlan, SM ;

Rapoport, B .

ENDOCRINOLOGY, 1996, 137 (07) :2664-2669

[6] The formation of thyrotropin receptor (TSHR) antibodies in a Graves' animal model requires the N-terminal segment of the TSHR extracellular domain [J].

Kikuoka, S ;

Shimojo, N ;

Yamaguchi, K ;

Watanabe, Y ;

Hoshioka, A ;

Hirai, A ;

Saito, Y ;

Tahara, K ;

Kohn, LD ;

Maruyama, N ;

Kohno, Y ;

Niimi, H .

ENDOCRINOLOGY, 1998, 139 (04) :1891-1898

[7]

KITA M, 1997, THYROID, V7

[8] MOLECULAR-CLONING OF THE COMPLEMENTARY DEOXYRIBONUCLEIC-ACID FOR HUMAN THYROID PEROXIDASE [J].

MAGNUSSON, RP ;

CHAZENBALK, GD ;

GESTAUTAS, J ;

SETO, P ;

FILETTI, S ;

DEGROOT, LJ ;

RAPOPORT, B .

MOLECULAR ENDOCRINOLOGY, 1987, 1 (11) :856-861

[9] MOLECULAR-CLONING, SEQUENCE AND FUNCTIONAL EXPRESSION OF THE CDNA FOR THE HUMAN THYROTROPIN RECEPTOR [J].

NAGAYAMA, Y ;

KAUFMAN, KD ;

SETO, P ;

RAPOPORT, B .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1989, 165 (03) :1184-1190

[10] EXCLUSION OF 2 MAJOR AREAS ON THYROID PEROXIDASE FROM THE IMMUNODOMINANT REGION CONTAINING THE CONFORMATIONAL EPITOPES RECOGNIZED BY HUMAN AUTOANTIBODIES [J].

NISHIKAWA, T ;

RAPOPORT, B ;

MCLACHLAN, SM .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 1994, 79 (06) :1648-1654