Membrane-stabilizing effect of δ-sleep-inducing peptide in stress

被引：3

作者：

Bondarenko, TI

Milyutina, NP

Mikhaleva, II

Noskova, NV

机构：

[1] Rostov Don State Univ, Dept Biochem & Microbiol, Rostov, Russia

[2] Russian Acad Sci, Lab Peptide Chem, MM Shemyakin & Yu A Ovchinnikov Inst Bioorgan Che, Moscow, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1998年 / 126卷 / 09期

关键词：

delta-sleep-inducing peptide; stress; erythrocyte membranes;

D O I：

10.1007/BF02447378

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Exposure of rats to cold stress leads to the accumulation of conjugated dienes and Schiffs bases and decreases superoxide dismutase and catalase activities. Plasma levels of extraerythrocytic hemoglobin and iron and the total peroxidase activity increase. This indicates destabilization of the erythrocyte plasma membrane in stress. Exogenous delta-sleep-inducing peptide decreases the intensity of lipid peroxidation by increasing the activity of the antioxidant enzymes and stabilizes the structure of the erythrocyte plasma membrane.

引用

页码：932 / 933

页数：2