Dendritic cell maturation in active immunotherapy strategies

被引:34
作者
Morse, MA [1 ]
Mosca, PJ [1 ]
Clay, TM [1 ]
Lyerly, HM [1 ]
机构
[1] Duke Univ, Ctr Med, Dept Med & Surg, Durham, NC 27710 USA
关键词
CD40; ligand; dendritic cell; IL-12; maturation;
D O I
10.1517/14712598.2.1.35
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
Dendritic cells (DCs) loaded with tumour antigen have become the centrepiece of clinical trials testing active immunotherapy strategies. Important variables include the source of DCs, the choice of antigens, the method of antigen loading and the route and timing of administration. Recently, the requirement for and the method of, DC maturation have been receiving particular attention. This is due to observations from in vitro studies and animal models demonstrating that mature DCs induce more potent antigen-specific T-cells responses than immature DCs. Furthermore, preliminary observations in human studies suggest that immature DCs might actually downregulate antigen-specific T-cell responses but mature DCs may augment them. Current studies are addressing how to define DC maturation, whether the variety of methods for maturation result in DC with similar T-cell stimulatory capacity, how to maintain the maturational status and whether maturation in vitro before immunisation, or in vivo, after immunisation, results in better DC function.
引用
收藏
页码:35 / 43
页数:9
相关论文
共 95 条
[1]   A dendritic-cell-derived C-C chemokine that preferentially attracts naive T cells [J].
Adema, GJ ;
Hartgers, F ;
Verstraten, R ;
deVries, E ;
Marland, G ;
Menon, S ;
Foster, J ;
Xu, YM ;
Nooyen, P ;
McClanahan, T ;
Bacon, KB ;
Figdor, CG .
NATURE, 1997, 387 (6634) :713-717
[2]  
ALAWAN MM, 2001, J IMMUNOL, V166, P338
[3]   A critical pole for p38 mitogen-activated protein kinase in the maturation of human blood-derived dendritic cells induced by lipopolysaccharide, TNF-α, and contact sensitizers [J].
Arrighi, JF ;
Rebsamen, M ;
Rousset, F ;
Kindler, V ;
Hauser, C .
JOURNAL OF IMMUNOLOGY, 2001, 166 (06) :3837-3845
[4]   Maturation and trafficking of monocyte-derived dendritic cells in monkeys: Implications for dendritic cell-based vaccines [J].
Barratt-Boyes, SM ;
Zimmer, MI ;
Harshyne, LA ;
Meyer, EM ;
Watkins, SC ;
Capuano, S ;
Murphey-Corb, M ;
Falo, LD ;
Donnenbrg, AD .
JOURNAL OF IMMUNOLOGY, 2000, 164 (05) :2487-2495
[5]   Improved methods for the generation of dendritic cells from nonproliferating progenitors in human blood [J].
Bender, A ;
Sapp, M ;
Schuler, G ;
Steinman, RM ;
Bhardwaj, N .
JOURNAL OF IMMUNOLOGICAL METHODS, 1996, 196 (02) :121-135
[6]   Enhanced dendritic cell maturation by TNF-α or cytidine-phosphate-guanosine DNA drives T cell activation in vitro and therapeutic anti-tumor immune responses in vivo [J].
Brunner, C ;
Seiderer, J ;
Schlamp, A ;
Bidlingmaier, M ;
Eigler, A ;
Haimerl, W ;
Lehr, HA ;
Krieg, AM ;
Hartmann, G ;
Endres, S .
JOURNAL OF IMMUNOLOGY, 2000, 165 (11) :6278-6286
[7]   Histamine induces CD86 expression and chemokine production by human immature dendritic cells [J].
Caron, G ;
Delneste, Y ;
Roelandts, E ;
Duez, C ;
Herbault, N ;
Magistrelli, G ;
Bonnefoy, JY ;
Pestel, J ;
Jeannin, P .
JOURNAL OF IMMUNOLOGY, 2001, 166 (10) :6000-6006
[8]   Dendritic cell biology and regulation of dendritic cell trafficking by chemokines [J].
Caux, C ;
Ait-Yahia, S ;
Chemin, K ;
de Bouteiller, O ;
Dieu-Nosjean, MC ;
Homey, B ;
Massacrier, C ;
Vanbervliet, B ;
Zlotnik, A ;
Vicari, A .
SPRINGER SEMINARS IN IMMUNOPATHOLOGY, 2000, 22 (04) :345-369
[9]   Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation [J].
Cella, M ;
Scheidegger, D ;
PalmerLehmann, K ;
Lane, P ;
Lanzavecchia, A ;
Alber, G .
JOURNAL OF EXPERIMENTAL MEDICINE, 1996, 184 (02) :747-752
[10]   Maturation, activation, and protection of dendritic cells induced by double-stranded RNA [J].
Cella, M ;
Salio, M ;
Sakakibara, Y ;
Langen, H ;
Julkunen, I ;
Lanzavecchia, A .
JOURNAL OF EXPERIMENTAL MEDICINE, 1999, 189 (05) :821-829