Innate immune detection of microbial nucleic acids

被引：232

作者：

Guertler, Claudia ^{[1
]}

Bowie, Andrew G. ^{[1
]}

机构：

[1] Trinity Coll Dublin, Trinity Biomed Sci Inst, Sch Biochem & Immunol, Dublin 2, Ireland

来源：

TRENDS IN MICROBIOLOGY | 2013年 / 21卷 / 08期

基金：

爱尔兰科学基金会; 美国国家卫生研究院;

关键词：

Toll-like receptors; RIG-I; antiviral immunity; cytosolic DNA sensing; STING; CYCLIC-DI-GMP; CYTOSOLIC DNA SENSOR; DOUBLE-STRANDED-RNA; SYSTEMIC-LUPUS-ERYTHEMATOSUS; TOLL-LIKE RECEPTORS; INDUCIBLE GENE-I; RIG-I; DENDRITIC CELLS; STRUCTURAL BASIS; ANTIVIRAL RESPONSES;

D O I：

10.1016/j.tim.2013.04.004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Detection of pathogen-derived nucleic acids by pattern recognition receptors (PRRs) is essential for the host to mount an appropriate immune response, which for viruses involves the induction of type I interferons (IFNs). By contrast, inappropriate activation of PRRs by self nucleic acids can lead to autoimmunity. Recent developments in PRR research have uncovered important new molecular details as to how Toll-like receptors (TLRs) and retinoic acid-inducible gene-I (RIG-I)-like receptors (RLRs) distinguish pathogen from self RNA, while the discovery of cytosolic DNA sensing pathways for IFN induction has revealed completely new innate signaling mechanisms, and also questions how innate immunity discriminates between self and non-self DNA, if at all.

引用

页码：413 / 420

页数：8

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