Pathways defective in the human premature aging disease Werner syndrome

被引：15

作者：

Bohr, VA ^{[1
]}

Brosh, RM ^{[1
]}

von Kobbe, C ^{[1
]}

Opresko, P ^{[1
]}

Karmakar, P ^{[1
]}

机构：

[1] NIA, Lab Mol Gerontol, NIH, Baltimore, MD 21224 USA

来源：

BIOGERONTOLOGY | 2002年 / 3卷 / 1-2期

关键词：

aging; DNA metabolism; DNA repair; Werner syndrome;

D O I：

10.1023/A:1015223917491

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and role of this protein is discussed in the light of how it functions in the aging process.

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收藏

页码：89 / 94

页数：6

相关论文

共 30 条

[1] The Werner syndrome protein is involved in RNA polymerase II transcription [J].

Balajee, AS ;

Machwe, A ;

May, A ;

Gray, MD ;

Oshima, J ;

Martin, GM ;

Nehlin, JO ;

Brosh, R ;

Orren, DK ;

Bohr, VA .

MOLECULAR BIOLOGY OF THE CELL, 1999, 10 (08) :2655-2668

[2] DNA repair and mutagenesis in Werner syndrome [J].

Bohr, VA ;

Pinto, NS ;

Nyaga, SG ;

Dianov, G ;

Kraemer, K ;

Seidman, MM ;

Brash, RM .

ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2001, 38 (2-3) :227-234

[3] Functional and physical interaction between WRN helicase and human replication protein A [J].

Brosh, RM ;

Orren, DK ;

Nehlin, JO ;

Ravn, PH ;

Kenny, MK ;

Machwe, A ;

Bohr, VA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (26) :18341-18350

[4] p53 modulates the exonuclease activity of Werner syndrome protein [J].

Brosh, RM ;

Harmakar, P ;

Sommers, JA ;

Yang, Q ;

Wang, XW ;

Spillare, EA ;

Harris, CC ;

Bohr, VA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (37) :35093-35102

[5] Werner's syndrome protein (WRN) migrates Holliday junctions and co-localizes with RPA upon replication arrest [J].

Constantinou, A ;

Tarsounas, M ;

Karow, JK ;

Brosh, RM ;

Bohr, VA ;

Hickson, ID ;

West, SC .

EMBO REPORTS, 2000, 1 (01) :80-84

[6]

Cooper MP, 2000, GENE DEV, V14, P907

[7]

Featherstone C, 1999, BRIT J CANCER, V80, P14

[8] MUTATOR PHENOTYPE OF WERNER SYNDROME IS CHARACTERIZED BY EXTENSIVE DELETIONS [J].

FUKUCHI, K ;

MARTIN, GM ;

MONNAT, RJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (15) :5893-5897

[9] The Werner syndrome protein is a DNA helicase [J].

Gray, MD ;

Shen, JC ;

KamathLoeb, AS ;

Blank, A ;

Sopher, BL ;

Martin, GM ;

Oshima, J ;

Loeb, LA .

NATURE GENETICS, 1997, 17 (01) :100-103

[10] RecQ DNA helicase is a suppressor of illegitimate recombination in Escherichia coli [J].

Hanada, K ;

Ukita, T ;

Kohno, Y ;

Saito, K ;

Kato, J ;

Ikeda, H .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (08) :3860-3865