Neurophysiological support of consciousness during waking and sleep

被引:58
作者
Gottesmann, C [1 ]
机构
[1] Univ Nice, Fac Sci, Psychophysiol Lab, F-06108 Nice 2, France
关键词
D O I
10.1016/S0301-0082(99)00014-3
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The aim of this review was to try to establish the current neurophysiological knowledge capable of explaining the differences of mental functioning during the different stages of sleep and waking. The analysis focused on the cortical state. Waking is characterized by electrophysiological activities (low voltage and gamma range EEG field patterns. unitary activities) and cerebral blood flow reflecting an activated state. On the contrary, neurochemical influences are marked by inhibitory afferent processes since dopamine. noradrenaline, serotonine and histamine tend, for the most part, to inhibit cortical neurons by diffuse release at the level of varicosities. During slow wave sleep, all these brain stem influences sustaining the cortical state decrease and transiently disappear just pi inr to onset of REM sleep. During REM sleep, pontine and mesopontine ascending activating influences invade the cortex in their turn while neurochemical inhibitory influences disappear with the exception of dopaminergic ones. We hypothesize that the activating influences acting on the cortex allow the latter to function, just as petrol makes an engine run, but that the diffuse inhibitory influences somehow regulate cortex functioning. Therefore, it is understandable that, during waking, mental activity is reflective and rational, and that psychological content is less intense during slow wave sleep. During REM sleep, the activated and mostly disinhibited state might induce the characteristic dream activity which appear to be rather ill-considered and illogical. Persistent dopaminergic input combined with the absence of noradrenergic input may induce psychological activities somewhat similar to those related to psychotic syndromes. Deactivation of part of the prefrontal cortex could contribute to this unusual mental activity. (C) 1999 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:469 / 508
页数:40
相关论文
共 103 条
[1]   CONCENTRATION OF HISTAMINE IN DIFFERENT PARTS OF BRAIN AND HYPOPHYSIS OF CAT AND ITS MODIFICATION BY DRUGS [J].
ADAM, HM ;
HYE, HKA .
BRITISH JOURNAL OF PHARMACOLOGY AND CHEMOTHERAPY, 1966, 28 (01) :137-&
[2]   REACTIVITY OF THE SOMESTHETIC S1 CORTEX DURING SLEEP AND WAKING IN THE RAT [J].
ARNAUD, C ;
GANDOLFO, G ;
GOTTESMANN, C .
BRAIN RESEARCH BULLETIN, 1979, 4 (06) :735-740
[3]   EYE MOVEMENTS DURING ACTIVE AND PASSIVE DREAMS [J].
BERGER, RJ ;
OSWALD, I .
SCIENCE, 1962, 137 (3530) :601-&
[4]   IS THE MECHANISM OF PREFRONTAL HYPOFUNCTION IN DEPRESSION THE SAME AS IN SCHIZOPHRENIA - REGIONAL CEREBRAL BLOOD-FLOW DURING COGNITIVE ACTIVATION [J].
BERMAN, KF ;
DORAN, AR ;
PICKAR, D ;
WEINBERGER, DR .
BRITISH JOURNAL OF PSYCHIATRY, 1993, 162 :183-192
[5]   EEG power densities (0.5-20 Hz) in different sleep-wake stages in rats [J].
Bjorvatn, B ;
Fagerland, S ;
Ursin, R .
PHYSIOLOGY & BEHAVIOR, 1998, 63 (03) :413-417
[6]   Inhibition of cortical acetylcholine release and cognitive performance by histamine H-3 receptor activation in rats [J].
Blandina, P ;
Giorgetti, M ;
Bartolini, L ;
Cecchi, M ;
Timmerman, H ;
Leurs, R ;
Pepeu, G ;
Giovannini, MG .
BRITISH JOURNAL OF PHARMACOLOGY, 1996, 119 (08) :1656-1664
[7]   DIFFERENTIAL PROJECTIONS OF NUCLEUS RAPHE DORSALIS AND NUCLEUS RAPHE CENTRALIS AS REVEALED BY AUTORADIOGRAPHY [J].
BOBILLIER, P ;
PETITJEAN, F ;
SALVERT, D ;
LIGIER, M ;
SEGUIN, S .
BRAIN RESEARCH, 1975, 85 :205-210
[8]   Involvement of endogenous nitric oxide signalling system in brain muscarinic acetylcholine receptor activation [J].
Borda, T ;
Genaro, A ;
Sterin-Borda, L ;
Cremaschi, G .
JOURNAL OF NEURAL TRANSMISSION, 1998, 105 (2-3) :193-204
[9]  
Bremer F, 1935, CR SOC BIOL, V118, P1235
[10]  
Bremer F., 1937, B ACAD ROY MED BELG, V4, P68