Diabetes, Abdominal Adiposity, and Atherogenic Dyslipoproteinemia in Women Compared With Men

被引:37
作者
Williams, Ken [1 ]
Tchernof, Andre [2 ]
Hunt, Kelly J. [3 ]
Wagenknecht, Lynne E. [4 ]
Haffner, Steven M. [5 ]
Suiderman, Allan D. [6 ]
机构
[1] KenAnCo Biostat, San Antonio, TX USA
[2] Univ Laval, Med Res Ctr, Mol Endocrinol & Oncol Res Ctr, Quebec City, PQ, Canada
[3] Med Univ S Carolina, Charleston, SC 29425 USA
[4] Wake Forest Univ, Sch Med, Dept Publ Hlth Sci, Winston Salem, NC 27109 USA
[5] Univ Texas Hlth Sci Ctr San Antonio, Dept Med, San Antonio, TX 78229 USA
[6] Mike Rosenbloom Lab Cardiovasc Res, Montreal, PQ, Canada
关键词
D O I
10.2337/db08-0787
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
OBJECTIVE-TO Understand why atherogenic risk differs more between diabetic and nondiabetic Women than between diabetic and nondiabetic men. RESEARCH DESIGN AND METHODS AND RESULTS-Measures of cardiovascular risk, body composition, and serum hormones from the baseline examinations of the Insulin Resistance Atherosclerosis Study off 524 nondiabetic women, 258 diabetic women, 421 nondiabetic men, and 220 diabetic men were compared to detect greater adverse differences in women than in men. Systolic blood pressure; apolipoprotein B (apoB)., total cholesterol; apoB-to-apoA-I ratio; non-HDL cholesterol; LDL particle count, small LDL, and intermediate-density lipoprotein by nuclear magnetic resonance; and C-reactive protein exhibited significant diabetes-sex interaction (P < 0.05). ApoB exhibited the most significant interaction (P = 0.0005). Age- and ethnicity-adjusted apoB means Were lower in nondiabetic women than nondiabetic men (102.4 vs. 106.8 mg/dl, P < 0.05) but higher in diabetes (115.7 vs. 110.2 mg/dl, P < 0.01). Plotted against. BMI, waist circumference was 6% higher and hip circumference 10% lower in diabetic than nondiabetic women (both P < 0.05), whereas the circumference measures did not differ conspicuously between diabetic and nondiabetic men. CONCLUSIONS-In diabetic women, an elevated level of atherogenic particles, as manifested by apoB and LDL particle count, which may result from abdominal adiposity, represents a major treatable cardiovascular risk factor. Diabetes 57:32893296,2008
引用
收藏
页码:3289 / 3296
页数:8
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