Polymorphism of norfloxacin:: Evidence of the enantiotropic relationship between polymorphs A and B

被引：48

作者：

Barbas, Rafael ^{[1
]}

Marti, Francesc ^{[1
]}

Prohens, Rafel ^{[1
]}

Puigjaner, Cristina ^{[1
]}

机构：

[1] Univ Barcelona, Unitat Quim Fina, Serv Cient Tecn, E-08028 Barcelona, Spain

来源：

CRYSTAL GROWTH & DESIGN | 2006年 / 6卷 / 06期

关键词：

D O I：

10.1021/cg060101u

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new interpretation of the polymorphic system of norfloxacin is described. Experimental evidence of the enantiotropic relationship between polymorphic forms A and B is provided by means of a solvent-mediated polymorphic transformation. Form B is the most stable one at room temperature, and it is enantiotropically related to the form A. Full characterization of both forms by X-ray crystallography, differential scanning calorimetry (DSC), IR, Raman, and solid-state NMR spectroscopy is provided.

引用

收藏

页码：1463 / 1467

页数：5

相关论文

共 16 条

[1] CHARACTERIZATION OF POLYMORPHISM OF GEPIRONE HYDROCHLORIDE [J].

BEHME, RJ ;

BROOKE, D ;

FARNEY, RF ;

KENSLER, TT .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1985, 74 (10) :1041-1046

[2]

Bernstein J., 2002, IUCR MONOGRAPHS CRYS, V14

[3] POLYMORPHISM OF PHARMACEUTICALS AND OTHER MOLECULAR-CRYSTALS .1. THEORY OF THERMODYNAMIC RULES [J].

BURGER, A ;

RAMBERGER, R .

MIKROCHIMICA ACTA, 1979, 2 (3-4) :259-271

[4] Preparation and characterization of polymorphs for an LTD(4) antagonist, RG 12525 [J].

Carlton, RA ;

Difeo, TJ ;

Powner, TH ;

Santos, I ;

Thompson, MD .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1996, 85 (05) :461-467

[5] Dealing with the impact of ritonavir polymorphs on the late stages of bulk drug process development [J].

Chemburkar, SR ;

Bauer, J ;

Deming, K ;

Spiwek, H ;

Patel, K ;

Morris, J ;

Henry, R ;

Spanton, S ;

Dziki, W ;

Porter, W ;

Quick, J ;

Bauer, P ;

Donaubauer, J ;

Narayanan, BA ;

Soldani, M ;

Riley, D ;

McFarland, K .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2000, 4 (05) :413-417

[6] Process development challenges to accommodate a late-appearing stable polymorph: A case study on the polymorphism and crystallization of a fast-track drug development compound [J].

Desikan, S ;

Parsons, RL ;

Davis, WP ;

Ward, JE ;

Marshall, WJ ;

Toma, PH .

ORGANIC PROCESS RESEARCH & DEVELOPMENT, 2005, 9 (06) :933-942

[7] Norfloxacin dihydrate [J].

Florence, AJ ;

Kennedy, AR ;

Shankland, N ;

Wright, E ;

Al-Rubayi, A .

ACTA CRYSTALLOGRAPHICA SECTION C-STRUCTURAL CHEMISTRY, 2000, 56 :1372-1373

[8] THERMAL-ANALYSIS AND CALORIMETRIC METHODS IN THE CHARACTERIZATION OF POLYMORPHS AND SOLVATES [J].

GIRON, D .

THERMOCHIMICA ACTA, 1995, 248 :1-59

[9]

Giron D, 2004, J THERM ANAL CALORIM, V77, P709, DOI 10.1023/B:JTAN.0000039005.51343.33

[10] PHARMACEUTICAL APPLICATIONS OF POLYMORPHISM [J].

HALEBLIAN, J ;

MCCRONE, W .

JOURNAL OF PHARMACEUTICAL SCIENCES, 1969, 58 (08) :911-+