Translocation of a calcium-permeable cation channel induced by insulin-like growth factor-I

被引：382

作者：

Kanzaki, M ^{[1
]}

Zhang, YQ ^{[1
]}

Mashima, H ^{[1
]}

Li, L ^{[1
]}

Shibata, H ^{[1
]}

Kojima, I ^{[1
]}

机构：

[1] Gunma Univ, Inst Mol & Cell Regulat, Dept Cell Biol, Maebashi, Gumma 3718512, Japan

来源：

NATURE CELL BIOLOGY | 1999年 / 1卷 / 03期

关键词：

D O I：

10.1038/11086

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Calcium plays a critical part in the regulation of cell growth, and growth factors stimulate calcium entry into cells through calcium-permeable channels. However, the molecular nature and regulation of calcium-permeable channels are still unclear at present. Here we report the molecular characterization of a calcium-permeable cation channel that is regulated by insulin-like growth factor-I (IGF-I). This channel, which we name growth-factor-regulated channel (GRC), belongs to the TRP-channel family and localizes mainly to intracellular poets under basal conditions. Upon stimulation of cells by IGF-I, GRC translocates to the plasma membrane. Thus, IGF-I augments calcium entry through GRC by regulating trafficking of the channel.

引用

页码：165 / 170

页数：6

共 25 条

[1] TRANSFECTION OF THE CD20 CELL-SURFACE MOLECULE INTO ECTOPIC CELL-TYPES GENERATES A CA2+ CONDUCTANCE FOUND CONSTITUTIVELY IN B-LYMPHOCYTES
BUBIEN, JK
ZHOU, LJ
BELL, PD
FRIZZELL, RA
TEDDER, TF
[J]. JOURNAL OF CELL BIOLOGY, 1993, 121 (05) : 1121 - 1132
[2] The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, MJ
Schumacher, MA
Tominaga, M
Rosen, TA
Levine, JD
Julius, D
[J]. NATURE, 1997, 389 (6653) : 816 - 824
[3] A capsaicin-receptor homologue with a high threshold for noxious heat
Caterina, MJ
Rosen, TA
Tominaga, M
Brake, AJ
Julius, D
[J]. NATURE, 1999, 398 (6726) : 436 - 441
[4] IMPROVED PATCH-CLAMP TECHNIQUES FOR HIGH-RESOLUTION CURRENT RECORDING FROM CELLS AND CELL-FREE MEMBRANE PATCHES
HAMILL, OP
MARTY, A
NEHER, E
SAKMANN, B
SIGWORTH, FJ
[J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1981, 391 (02): : 85 - 100
[5] 1-PHOSPHATIDYLINOSITOL 3-KINASE ACTIVITY IS REQUIRED FOR INSULIN-STIMULATED GLUCOSE-TRANSPORT BUT NOT FOR RAS ACTIVATION IN CHO CELLS
HARA, K
YONEZAWA, K
SAKAUE, H
ANDO, A
KOTANI, K
KITAMURA, T
KITAMURA, Y
UEDA, H
STEPHENS, L
JACKSON, TR
HAWKINS, PT
DHAND, R
CLARK, AE
HOLMAN, GD
WATERFIELD, MD
KASUGA, M
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (16) : 7415 - 7419
[6] From receptor to transporter: insulin signalling to glucose transport
Holman, GD
Kasuga, M
[J]. DIABETOLOGIA, 1997, 40 (09) : 991 - 1003
[7] EXPRESSION OF CALCIUM-PERMEABLE CATION CHANNEL CD20 ACCELERATES PROGRESSION THROUGH THE G(1) PHASE IN BALB/C 3T3 CELLS
KANZAKI, M
SHIBATA, H
MOGAMI, H
KOJIMA, I
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (22) : 13099 - 13104
[8] Activation of a calcium-permeable cation channel CD20 expressed in Balb/c 3T3 cells by insulin-like growth factor-1
Kanzaki, M
Nie, L
Shibata, H
Kojima, I
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (08) : 4964 - 4969
[9] KOIIMA I, 1988, J BIOL CHEM, V263, P16561
[10] KOIIMA I, 1993, J BIOL CHEM, V268, P1003

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