Hepatocellular Carcinoma - from Immunobiology to Immunotherapy

被引:8
作者
Flecken, T. [1 ]
Schmidt, N. [1 ]
Spangenberg, H. C. [1 ]
Thimme, R. [1 ]
机构
[1] Univ Freiburg Klinikum, Innere Med Abt 2, Freiburg, Germany
来源
ZEITSCHRIFT FUR GASTROENTEROLOGIE | 2012年 / 50卷 / 01期
关键词
hepatocellular carcinoma; liver; tumour immunology; hepatitis C; hepatitis B; immune-based therapy; T-CELL RESPONSES; TELOMERASE REVERSE-TRANSCRIPTASE; TUMOR-SUPPRESSOR GENE; GROWTH-FACTOR-ALPHA; NF-KAPPA-B; DENDRITIC CELLS; OXIDATIVE STRESS; UP-REGULATION; LIVER-CANCER; PHASE-II;
D O I
10.1055/s-0031-1282002
中图分类号
R57 [消化系及腹部疾病];
学科分类号
100201 [内科学];
摘要
Hepatocellular carcinoma (HCC) is the fifth most common malignancy worldwide with an increasing incidence. The clinical outcome is influenced by the underlying liver cirrhosis, the size of the tumour at the time of diagnosis and the few therapeutic options currently available. In recent years there has been a lot of progress in the understanding of HCC immunobiology. This review summarizes our current knowledge of HCC biology, the role of chronic inflammation in carcinogenesis and the role of tumour-specific immune responses. Furthermore, we will present potentially new, immune-based therapies that might open up new avenues for the treatment of HCC.
引用
收藏
页码:47 / 56
页数:10
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