Review on the Angiotensin-I-Converting Enzyme (ACE) Inhibitor Peptides from Marine Proteins

被引：92

作者：

He, Hai-Lun ^{[1
]}

Liu, Dan ^{[1
]}

Ma, Chang-Bei ^{[1
]}

机构：

[1] Cent S Univ, Sch Biol Sci & Technol, Changsha 410013, Hunan, Peoples R China

来源：

APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY | 2013年 / 169卷 / 03期

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

Angiotensin-I-converting enzyme (ACE); Antihypertensive; ACE-inhibitory activity; Peptides; Marine organisms; ANTIHYPERTENSIVE ACTIVITY; SPECTROPHOTOMETRIC ASSAY; BIOLOGICAL-ACTIVITY; BIOACTIVE PEPTIDES; FOOD PROTEINS; FRAME PROTEIN; MUSCLE; IDENTIFICATION; HYDROLYSATE; MILK;

D O I：

10.1007/s12010-012-0024-y

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

Hypertension is now a major problem threatening people health in the world. Angiotensin-I-converting enzyme (ACE) plays an important physiological role in regulation of blood pressure via conversion of angiotensin I to angiotensin II. Inhibition of ACE may have an antihypertensive effect as a consequence of a decrease in blood pressure. A number of terrestrial-derived peptides have been reviewed about their in vitro and in vivo ACE-inhibitory activities. Marine organisms are potentially an untapped source of drugs and value-added food production. The aim of this review is to discuss the marine-derived ACE-inhibitory peptides from sources, production, structure aspects, and their future prospects as functional food or novel therapeutic drug candidates.

引用

页码：738 / 749

页数：12

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