Abnormal thyroid function tests in infants with congenital hypothyroidism: The influence of soy-based formula

被引:50
作者
Jabbar, MA [1 ]
Larrea, J [1 ]
Shaw, RA [1 ]
机构
[1] HURLEY MED CTR,RES DEPT,FLINT,MI 48503
关键词
soy formula; thyroxine; thyrotropin; hypothyroidism;
D O I
10.1080/07315724.1997.10718686
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Objective: To assess the etiology of hyperthyroxinemia or hyperthyrotropinemia in infants with congenital In hypothyroidism who are on replacement therapy with L-thyroxine. Methods: These infants were treated with recommended doses of L-thyroxine following the diagnosis of congenital hypothyroidism. Because of hyperthyroxinemia (2 patients) and hyperthyrotropinemia (1 patient), medication compliance and dietary practice (formula type, age of introduction, and discontinuation or change of the formula) were assessed. Clinical evaluation was also performed. Results: Elevated thyroxine level in 2 infants was associated with discontinuation of soy formula 4 weeks previously; reduction of L-thyroxine dose normalized serum levels in both of these infants. In the third infant, who received soy formula from 1 week of age, TSH remained elevated despite incremental L-thyroxine doses of 19 mu g/kg/day; discontinuation of soy formula was followed by normalization of the TSH in 3 weeks and helped attain a subsequent decrement of L-thyroxine dose to 8.6 mu g/kg/day. Neither the hyperthyroxinemia nor hyperthyrotropinemia in these infants was associated with any adverse behavioral-developmental consequence. Conclusion: When initiating soy-formula feeding in infants with congenital hypothyroidism, the L-thyroxine dose should be increased because of significant reduction in intestinal absorption; conversely, when soy feeding is discontinued, the L-thyroxine dose should be decreased.
引用
收藏
页码:280 / 282
页数:3
相关论文
共 9 条
[1]   THE ROLE OF THE GASTROINTESTINAL TRACT, INCLUDING THE LIVER, IN THE METABOLISM OF RADIOTHYROXINE [J].
ALBERT, A ;
KEATING, FR .
ENDOCRINOLOGY, 1952, 51 (05) :427-443
[2]   SOY FLOUR AND FECAL THYROXINE LOSS IN RATS [J].
BECK, RN .
ENDOCRINOLOGY, 1958, 62 (05) :587-592
[3]  
CHORAZY PA, 1995, PEDIATRICS, V96, P148
[4]   COMPARISON OF BREAST, COW, AND SOY FEEDINGS IN THE PREVENTION OF ONSET OF ALLERGIC DISEASE - A 15-YEAR PROSPECTIVE-STUDY [J].
GRUSKAY, FL .
CLINICAL PEDIATRICS, 1982, 21 (08) :486-491
[5]   OCCURRENCE OF GOITER IN AN INFANT ON A SOY DIET [J].
HYDOVITZ, JD .
NEW ENGLAND JOURNAL OF MEDICINE, 1960, 262 (07) :351-353
[6]   DOES BREAST-FEEDING PROTECT THE HYPOTHYROID INFANT WHOSE CONDITION IS DIAGNOSED BY NEWBORN SCREENING [J].
ROVET, JF .
AMERICAN JOURNAL OF DISEASES OF CHILDREN, 1990, 144 (03) :319-323
[7]   SOYBEAN GOITER - REPORT OF 3 CASES [J].
SHEPARD, TH ;
PYNE, GE ;
KIRSCHVINK, JF ;
MCLEAN, M .
NEW ENGLAND JOURNAL OF MEDICINE, 1960, 262 (22) :1099-1103
[8]   THYROXINE EXCRETION, A POSSIBLE CAUSE OF GOITER [J].
VANMIDDLESWORTH, L .
ENDOCRINOLOGY, 1957, 61 (05) :570-573
[9]  
VANWYK JJ, 1959, PEDIATRICS, V24, P752