Lepirudin anticoagulation for heparin-induced thrombocytopenia

被引：43

作者：

Deitcher, SR

Topoulos, AP

Bartholomew, JR

Kichuk-Chrisant, MR

机构：

[1] Cleveland Clin Fdn, Dept Cardiovasc Med, Cleveland, OH 44195 USA

[2] Cleveland Clin Fdn, Dept Pediat Cardiol, Cleveland, OH 44195 USA

来源：

JOURNAL OF PEDIATRICS | 2002年 / 140卷 / 02期

关键词：

D O I：

10.1067/mpd.2002.121384

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Lepirudin is indicated for anticoagulation in patients with heparin-induced thrombocytopenia (HIT). We describe 2 cases of HIT and thrombosis in children with heart disease, including one that required extracorporeal membrane oxygenation. Lepirudin, dosed in the recommended adult weight-based fashion, was an effective antithrombotic agent in pediatric patients with HIT.

引用

收藏

页码：264 / 266

页数：3

相关论文

共 12 条

[1]

Chong BH, 1998, SEMIN HEMATOL, V35, P3

[2] ANNOTATION - HEPARIN-INDUCED THROMBOCYTOPENIA [J].

CHONG, BH .

BRITISH JOURNAL OF HAEMATOLOGY, 1995, 89 (03) :431-439

[3] Lepirudin (recombinant hirudin) for parenteral anticoagulation in patients with heparin-induced thrombocytopenia [J].

Greinacher, A ;

Janssens, U ;

Berg, G ;

Böck, M ;

Kwasny, H ;

Kemkes-Matthes, B ;

Eichler, P ;

Völpel, H ;

Pötzsch, B ;

Luz, M .

CIRCULATION, 1999, 100 (06) :587-593

[4] Recombinant hirudin (Lepirndin) provides safe and effective anticoagulation in patients with heparin-induced thrombocytopenia -: A prospective study [J].

Greinacher, A ;

Völpel, H ;

Janssens, U ;

Hach-Wunderle, V ;

Kemkes-Matthes, B ;

Eichler, P ;

Mueller-Velten, HG ;

Pötzsch, B .

CIRCULATION, 1999, 99 (01) :73-80

[5] Heparin as a cause of thrombus progression - Heparin-associated thrombocytopenia is an important differential diagnosis in paediatric patients even with normal platelet counts [J].

Klement, D ;

Rammos, S ;

vonKries, R ;

Kirschke, W ;

Kniemeyer, HW ;

Greinacher, A .

EUROPEAN JOURNAL OF PEDIATRICS, 1996, 155 (01) :11-14

[6]

Potzsch B, 1997, THROMB HAEMOSTASIS, V77, P920

[7]

Pouplard C, 1999, AM J CLIN PATHOL, V111, P700

[8] Heparin-induced thrombocytopenia in paediatric patients - a review of the literature and a new case treated with danaparoid sodium [J].

Ranze, O ;

Ranze, P ;

Magnani, HN ;

Greinacher, A .

EUROPEAN JOURNAL OF PEDIATRICS, 1999, 158 (Suppl 3) :S130-S133

[9]

ROETHIG HJ, 1991, CLIN PHARM BIOTECHNO, P227

[10] Pediatric heparin-induced thrombocytopenia: Management with Danaparoid (orgaran) [J].

Saxon, BR ;

Black, MD ;

Edgell, D ;

Noel, D ;

Leaker, MT .

ANNALS OF THORACIC SURGERY, 1999, 68 (03) :1076-1078