Neuroprotective effect of FK506, an immunosuppressant, on transient global ischemia in gerbil

被引：66

作者：

Tokime, T

Nozaki, K

Kikuchi, H

机构：

[1] Department of Neurosurgery, Faculty of Medicine, Kyoto University, Kyoto, 606, 54 Shogoin Kawahara-cho, Sakyo-ku

来源：

NEUROSCIENCE LETTERS | 1996年 / 206卷 / 2-3期

关键词：

delayed neuronal death; global ischemia; nitric oxide; FK506; 7-nitro indazole; gerbil;

D O I：

10.1016/S0304-3940(96)12438-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Delayed neuronal death (DND) in CA1 region after transient global ischemia is a well-known phenomenon, but its mechanism has not been clarified. In order to examine the involvement of nitric oxide (NO) in DND, 7-nitro indazole (7NI), a selective neuronal NO synthase (nNOS) inhibitor, and FK506, an immunosuppressant which also inhibits nNOS, were administered intraperitoneally during and after transient global ischemia in gerbil. FK506 moderately ameliorated DND in a dose-dependent manner. However, 7NI showed only minor neuroprotective effects. These results show that DND is not mainly mediated by NO production via nNOS, and FK506 acts as a neuroprotective agent via unknown pathways other than nNOS inhibition.

引用

页码：81 / 84

页数：4

共 18 条

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