Osteopontin: A novel regulator at the cross roads of inflammation, obesity and diabetes

被引：367

作者：

Kahles, Florian

Findeisen, Hannes M.

Bruemmer, Dennis ^{[1
]}

机构：

[1] Univ Kentucky, Coll Med, Saha Cardiovasc Res Ctr, Div Cardiovasc Med,Gill Heart Inst, Lexington, KY USA

来源：

MOLECULAR METABOLISM | 2014年 / 3卷 / 04期

关键词：

Osteopontin; Biomineralization; Tissue remodeling; Inflammation: Obesity; Insulin resistance; Insulin sensitivity; Non-alcoholic fatty liver disease: Diabetic nephropathy;

D O I：

10.1016/j.molmet.2014.03.004

中图分类号：

R5 [内科学];

学科分类号：

100201 [内科学];

摘要：

Since its first description more than 20 years ago osteopontin has emerged as an active player in many physiological and pathological processes, including biomineralization, tissue remodeling and inflammation. As an extracellular matrix protein and proinflammatory cytokine osteopontin is thought to facilitate the recruitment of monocytes/macrophages and to mediate cytokine secretion in leukocytes. Modulation of immune cell response by osteopontin has been associated with various inflammatory diseases and may play a pivotal role in the development of adipose tissue inflammation and insulin resistance. Here we summarize recent findings on the role of osteopontin in metabolic disorders, particularly focusing on diabetes and obesity. (C) 2014 The Authors. Published by Elsevier GmbH.

引用

页码：384 / 393

页数：10

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