Mitotic instability associated with late genomic changes in bone and soft tissue tumours

被引：20

作者：

Gisselsson, D ^{[1
]}

Pålsson, E ^{[1
]}

Yu, C ^{[1
]}

Mertens, F ^{[1
]}

Mandahl, N ^{[1
]}

机构：

[1] Univ Lund Hosp, Dept Clin Genet, SE-22185 Lund, Sweden

来源：

CANCER LETTERS | 2004年 / 206卷 / 01期

关键词：

sarcoma; breakage-fusion-bridge cycles; centrosome; chromosome instability; multipolar mitosis;

D O I：

10.1016/j.canlet.2003.10.022

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

One source of genomic instability in tumours is abnormal mitotic segregation of chromosomes. Evaluation of chromosome segregation and cytogenetic aberrations in 28 bone and soft tissue neoplasms revealed few mitotic disturbances in benign lesions, whereas most of the malignant tumours, except for chondrosarcomas, showed anaphase bridges and/or multipolar mitoses. Only cases with chromosomal imbalances exhibited these defects and they were not present in any of the cases with sole primary changes, indicating that mitotic instability is established relatively late in mesenchymal tumour development. Most cases with multipolar mitoses exhibited abnormal centrosome configurations. However, induction of supernumerary centrioles in vitro failed to produce mitotic abnormalities in normal cells, indicating that additional disturbances of the cell division machinery are required for the generation of mitotic multipolarity. (C) 2003 Elsevier Ireland Ltd. All rights reserved.

引用

页码：69 / 76

页数：8

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