RhoGAP: The next big thing for small mice?

被引：5

作者：

Birnbaum, MJ ^{[1
]}

机构：

[1] Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

来源：

DEVELOPMENTAL CELL | 2002年 / 2卷 / 05期

关键词：

D O I：

10.1016/S1534-5807(02)00183-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The size of an organism is determined by the number and size of its constituent cells. The insulin/IGF-1 signaling systems have been long recognized to play a critical role in the determination of body size. Now the generation of mice deficient for a RhoGAP suggests that this small G protein might also regulate the growth of animals.

引用

页码：521 / 523

页数：3

共 8 条

[1] Turning down insulin signaling [J].

Birnbaum, MJ .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 108 (05) :655-659

[2] Akt1/PKBα is required for normal growth but dispensable for maintenance of glucose homeostasis in mice [J].

Cho, H ;

Thorvaldsen, JL ;

Chu, QW ;

Feng, F ;

Birnbaum, MJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (42) :38349-38352

[3]

Day SJ, 2000, DEVELOPMENT, V127, P2977

[4] MICE CARRYING NULL MUTATIONS OF THE GENES ENCODING INSULIN-LIKE GROWTH FACTOR-I (IGF-1) AND TYPE-1 IGF RECEPTOR (IGF1R) [J].

LIU, JP ;

BAKER, J ;

PERKINS, AS ;

ROBERTSON, EJ ;

EFSTRATIADIS, A .

CELL, 1993, 75 (01) :59-72

[5] Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein [J].

Rudolph, D ;

Tafuri, A ;

Gass, P ;

Hämmerling, G ;

Arnold, B ;

Schütz, G .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (08) :4481-4486

[6] Modulation of CREB activity by the Rho GTPase regulates cell and organism size during mouse embryonic development [J].

Sordella, R ;

Classon, M ;

Hu, KQ ;

Matheson, SF ;

Brouns, MR ;

Fine, B ;

Zhang, L ;

Takami, H ;

Yamada, Y ;

Settleman, J .

DEVELOPMENTAL CELL, 2002, 2 (05) :553-565

[7] Regulation of pancreatic β-cell growth and survival by the serine/threonine protein kinase Akt1/PKBα [J].

Tuttle, RL ;

Gill, NS ;

Pugh, W ;

Lee, JP ;

Koeberlein, B ;

Furth, EE ;

Polonsky, KS ;

Naji, A ;

Birnbaum, MJ .

NATURE MEDICINE, 2001, 7 (10) :1133-1137

[8] Cell-autonomous regulation of cell and organ growth in Drosophila by Akt/PKB [J].

Verdu, J ;

Buratovich, MA ;

Wilder, EL ;

Birnbaum, MJ .

NATURE CELL BIOLOGY, 1999, 1 (08) :500-506

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