Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease

被引：438

作者：

Bateman, Randall J. ^{[1
]}

Aisen, Paul S. ^{[2
]}

De Strooper, Bart ^{[3
,4
]}

Fox, Nick C. ^{[5
]}

Lemere, Cynthia A. ^{[6
]}

Ringman, John M. ^{[7
]}

Salloway, Stephen ^{[8
]}

Sperling, Reisa A. ^{[9
]}

Windisch, Manfred ^{[10
]}

Xiong, Chengjie ^{[11
]}

机构：

[1] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

[2] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[3] Flanders Inst Biotechnol VIB, Dept Mol & Dev Genet, Louvain, Belgium

[4] Katholieke Univ Leuven, Ctr Human Genet, B-3000 Louvain, Belgium

[5] UCL, Dementia Res Ctr, UCL Inst Neurol, London WC1N 3BG, England

[6] Harvard Univ, Ctr Neurol Dis, Brigham & Womens Hosp, Sch Med, Boston, MA 02115 USA

[7] Univ Calif Los Angeles, Mary S Easton Ctr Alzheimers Dis Res, Dept Neurol, David Geffen Sch Med, Los Angeles, CA 90095 USA

[8] Butler Hosp, Dept Neurol, Memory & Aging Program, Providence, RI 02906 USA

[9] Harvard Univ, Ctr Alzheimer Res & Treatment, Brigham & Womens Hosp,Med Sch, Alzheimers Dis Res Ctr,Massachusetts Gen Hosp, Boston, MA 02115 USA

[10] JSW LifeSci GmbH, A-8074 Grambach, Austria

[11] Washington Univ, Div Biostat, St Louis, MO 63110 USA

来源：

ALZHEIMERS RESEARCH & THERAPY | 2011年 / 3卷 / 01期

基金：

美国国家卫生研究院; 英国医学研究理事会;

关键词：

AMYLOID PRECURSOR PROTEIN; POSITRON-EMISSION-TOMOGRAPHY; CEREBROSPINAL-FLUID; BETA DEPOSITION; PRESENILIN MUTATIONS; MUTANT PRESENILIN-1; SENILE PLAQUES; MOUSE MODEL; IN-VIVO; ONSET;

D O I：

10.1186/alzrt59

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Autosomal-dominant Alzheimer's disease has provided significant understanding of the pathophysiology of Alzheimer's disease. The present review summarizes clinical, pathological, imaging, biochemical, and molecular studies of autosomal-dominant Alzheimer's disease, highlighting the similarities and differences between the dominantly inherited form of Alzheimer's disease and the more common sporadic form of Alzheimer's disease. Current developments in autosomal-dominant Alzheimer's disease are presented, including the international Dominantly Inherited Alzheimer Network and this network's initiative for clinical trials. Clinical trials in autosomal-dominant Alzheimer's disease may test the amyloid hypothesis, determine the timing of treatment, and lead the way to Alzheimer's disease prevention.

引用

页数：13

共 89 条

[1]

Clinical and neuropathological features of the Arctic APP gene mutation causing early-onset Alzheimer disease [J].