Derivation of a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES).

被引：7

作者：

Ahmed, S ^{[1
]}

James, K ^{[1
]}

机构：

[1] Kingston Univ, Sch Appl Chem, Kingston upon Thames KT1 2EE, Surrey, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(99)00245-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

We have determined a possible transition-state for the reaction catalysed by the enzyme Estrone Sulfatase (ES) - as a representation of the active site. Using the derived structure, we have superimposed several steroidal and non-steroidal inhibitors in an attempt to rationalise the inhibitory activity of a number of potent inhibitors. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1645 / 1650

页数：6

共 9 条

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