Risk Factors for Lymph Node Metastasis in pT1 and pT2 Rectal Cancer: A Single-Institute Experience in 943 Patients and Literature Review

被引：76

作者：

Chang, Hao-Cheng ^{[1
]}

Huang, Shih-Chiang ^{[2
]}

Chen, Jinn-Shiun ^{[1
]}

Tang, Reiping ^{[1
]}

Changchien, Chung Rong ^{[1
]}

Chiang, Jy-Ming ^{[1
]}

Yeh, Chien-Yuh ^{[1
]}

Hsieh, Pao-Shiu ^{[1
]}

Tsai, Wen-Sy ^{[1
]}

Hung, Hsin-Yuan ^{[1
]}

You, Jeng-Fu ^{[1
]}

机构：

[1] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp Linkou, Dept Surg,Colorectal Sect, Tao Yuan, Taiwan

[2] Chang Gung Univ, Coll Med, Chang Gung Mem Hosp Linkou, Dept Pathol,Colorectal Sect, Tao Yuan, Taiwan

来源：

ANNALS OF SURGICAL ONCOLOGY | 2012年 / 19卷 / 08期

关键词：

T2; COLORECTAL-CANCER; LOCAL EXCISION; TRANSANAL EXCISION; T1; ADENOCARCINOMA; ADJUVANT THERAPY; VENOUS INVASION; PREDICT; CARCINOMAS; RECURRENCE; RESECTION;

D O I：

10.1245/s10434-012-2303-9

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 [肿瘤学];

摘要：

Local excision has become an alternative for radical resection in rectal cancer for selected patients. The purpose of this study was to assess the clinicopathologic factors determining lymph node metastasis (LNM) in patients with T1-2 rectal cancer. Between January 1995 and December 2009, a total of 943 patients with pT1 or pT2 rectal adenocarcinoma received radical resection at a single institution. Clinicopathologic factors were evaluated by univariate and multivariate analyses to identify risk factors for LNM. A total of 943 patients (544 men and 399 women) treated for T1-2 rectal cancer were included in this study. LNM was found in 188 patients (19.9%). In multivariate analysis, lymphovascular invasion (LVI; P < 0.001, hazard ratio 11.472), poor differentiation (PD; P = 0.007, hazard ratio 3.218), and depth of invasion (presence of pT2; P = 0.032, hazard ratio 1.694) were significantly related to nodal involvement. The incidence for LNM lesions in the presence of LVI, PD, and pT2 was 68.8, 50.0, and 23.1%, respectively, while that for pT1 carcinomas with no LVI or PD was 7.5%. LVI, PD, and pT2 are independent risk factors predicting LNM in pT1-2 rectal carcinoma.

引用

页码：2477 / 2484

页数：8

共 42 条

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