Effectiveness of green tea tannin on rats with chronic renal failure

被引：54

作者：

Yokozawa, T ^{[1
]}

Chung, HY ^{[1
]}

He, LQ ^{[1
]}

Oura, H ^{[1
]}

机构：

[1] PUSAN NATL UNIV, COLL PHARM, PUSAN 609735, SOUTH KOREA

来源：

BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 1996年 / 60卷 / 06期

关键词：

green tea; tannin; chronic renal failure; rat;

D O I：

10.1271/bbb.60.1000

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of green tea tannin on nephrectomized rats were examined, There were increases in blood urea nitrogen, serum creatinine, and urinary protein, and a decrease in creatinine clearance in the nephrectomized control rats, whereas better results for these parameters were obtained in rats given green tea tannin after nephrectomy, demonstrating a suppressed progression of the renal failure. When the renal parenchyma was partially resected, the remnant kidney showed a decrease in the activity of radical scavenger enzymes. Green tea tannin, however, was found to lighten the kidney under such oxidative stress. Mesangial proliferation and glomerular sclerotic lesions, which were conspicuous in the rats that were not given green tea tannin after nephrectomy, were also relieved.

引用

页码：1000 / 1005

页数：6

共 25 条

[1]

Aebi HI, 1983, METHOD ENZYMAT AN, P673, DOI [DOI 10.1016/B978-0-12-091302-2.50032-3, 10.1016/B978-0-12-091302-2.50032-3]

[2]

BRENNER BM, 1982, NEW ENGL J MED, V307, P652, DOI 10.1056/NEJM198209093071104

[3]

BRENNER BM, 1994, HARRISONS PRINCIPLES, P1274

[4] TISSUE SULFHYDRYL GROUPS [J].

ELLMAN, GL .

ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, 1959, 82 (01) :70-77

[5] REMNANT KIDNEY HYPERMETABOLISM AND PROGRESSION OF CHRONIC RENAL-FAILURE [J].

HARRIS, DCH ;

CHAN, L ;

SCHRIER, RW .

AMERICAN JOURNAL OF PHYSIOLOGY, 1988, 254 (02) :F267-F276

[6]

ICHIKAWA I, 1989, J JPN PEDIAT SOC, V93, P2371

[7] THE PATHOBIOLOGY OF THE MESANGIUM [J].

KASHGARIAN, M ;

STERZEL, RB .

KIDNEY INTERNATIONAL, 1992, 41 (03) :524-529

[8]

LOWRY OH, 1951, J BIOL CHEM, V193, P265

[9] PHYSIOLOGY OF THE MESANGIAL CELL [J].

MENE, P ;

SIMONSON, MS ;

DUNN, MJ .

PHYSIOLOGICAL REVIEWS, 1989, 69 (04) :1347-1424

[10]

MORRISON AB, 1966, METHODS ACHIEVEMENT, V1, P455

← 1 2 3 →