New genes in inflammatory bowel disease: lessons for complex diseases?

被引：183

作者：

Gaya, DR ^{[1
]}

Russell, RK ^{[1
]}

Nimmo, ER ^{[1
]}

Satsangi, J ^{[1
]}

机构：

[1] Univ Edinburgh, Western Gen Hosp, Mol Med Ctr, Gastrointestinal Unit, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

LANCET | 2006年 / 367卷 / 9518期

基金：

英国惠康基金;

关键词：

D O I：

10.1016/S0140-6736(06)68345-1

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The chronic inflammatory bowel diseases Crohn's disease and ulcerative colitis are common causes of gastrointestinal disease in northern Europe, affecting as many as one in 250 people. Although mortality is low, morbidity associated with these diseases is substantial. We review the recent advances in the genetics of inflammatory bowel disease, with particular emphasis on the data that have been generated since the discovery of the CARD15 (NOD2) gene in 2001.

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收藏

页码：1271 / 1284

页数：14

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