Graphene oxide can induce in vitro and in vivo mutagenesis

被引：106

作者：

Liu, Yuanyuan ^{[1
,2
]}

Luo, Yi ^{[3
]}

Wu, Jing ^{[4
]}

Wang, Yinsong ^{[1
,2
]}

Yang, Xiaoying ^{[1
,2
]}

Yang, Rui ^{[1
,2
]}

Wang, Baiqi ^{[1
,2
]}

Yang, Jinrong ^{[1
,2
]}

Zhang, Ning ^{[1
,2
,3
]}

机构：

[1] Tianjin Med Univ, Tianjin Key Lab Technol Enabling Dev Clin Therape, Res Ctr Basic Med Sci, Tianjin 300070, Peoples R China

[2] Tianjin Med Univ, Tianjin Key Lab Technol Enabling Dev Clin Therape, Sch Pharm, Tianjin 300070, Peoples R China

[3] Tianjin Med Univ, Tianjin Canc Inst & Hosp, Tianjin 300060, Peoples R China

[4] Tianjin Third Cent Hosp, Tianjin 300170, Peoples R China

来源：

SCIENTIFIC REPORTS | 2013年 / 3卷

基金：

中国国家自然科学基金; 中国博士后科学基金;

关键词：

DNA; EXPRESSION; ACID; MICE; ATM;

D O I：

10.1038/srep03469

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

070301 [无机化学]; 070403 [天体物理学]; 070507 [自然资源与国土空间规划学]; 090105 [作物生产系统与生态工程];

摘要：

Graphene oxide (GO) has attracted enormous interests due to its extraordinary properties. Recent studies have confirmed the cytotoxicity of GO, we further investigate its mutagenic potential in this study. The results showed that GO interfered with DNA replication and induced mutagenesis at molecular level. GO treatments at concentrations of 10 and 100 mu g/mL altered gene expression patterns at cellular level, and 101 differentially expressed genes mediated DNA-damage control, cell apoptosis, cell cycle, and metabolism. Intravenous injection of GO at 4 mg/kg for 5 consecutive days clearly induced formation of micronucleated polychromic erythrocytes in mice, and its mutagenesis potential appeared to be comparable to cyclophosphamide, a classic mutagen. In conclusion, GO can induce mutagenesis both in vitro and in vivo, thus extra consideration is required for its biomedical applications.

引用

页数：8

共 39 条

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