Lipopolysaccharide-mediated immobility in mice: Reversal by cyclooxygenase enzyme inhibitors

被引:37
作者
Jain, NK [1 ]
Kulkarni, SK [1 ]
Singh, A [1 ]
机构
[1] Panjab Univ, Inst Pharmaceut Sci, Div Pharmacol, Chandigarh 160014, India
来源
METHODS AND FINDINGS IN EXPERIMENTAL AND CLINICAL PHARMACOLOGY | 2001年 / 23卷 / 08期
关键词
cyclooxygenase inhibitor; despair behavior; lipopolysaccharide;
D O I
10.1358/mf.2001.23.8.662131
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Endotoxin (lipopolysaccharide, LPS) is known to activate the hypothalamo-pituitary adrenocortical axis, as well as norepinephrine and indolamine metabolism. In the present study we examined the effects of systemically administered LPS on forced swimming-induced despair behavior in mice. LPS (50 mug/mouse i.p.) time-dependently enhanced the forced swimming-induced immobility period. The increase in immobility. time was highest after 2 h of LPS administration. Desipramine (10 mg/kg), a tricycle antidepressant, or fluoxetine (10 mg/kg), a serotonin reuptake inhibitor, significantly, reversed the LPS-induced increase in immobility time. Cyclooxygenase inhibitors nimesulide (1, 2 and 5 mg/kg), naproxen (10 mg/kg) and rofecoxib (2 mg/kg) did not alter the despair behavior per se. Nimesulide (10 mg/kg) did reverse immobility. Nimesulide (2 mg/kg), naproxen (10 mg/kg) and rofecoxib (2 mg/kg) significantly reversed LPS-mediated despair behavior. The present study demonstrated that LPS-induced inflammatory responses in the brain may cause despair behavior Reversal with a inhibitor indicates the role of prostaglandins in despair behavior. (C) 2001 Prous Science. All rights reserved.
引用
收藏
页码:441 / 444
页数:4
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