Role of immunoexpression of nitric oxide synthases by Hodgkin and Reed-Sternberg cells on apoptosis deregulation and on clinical outcome of classical Hodgkin lymphoma

被引：21

作者：

Campos, Antonio H. J. F. M. ^{[1
]}

Aldred, Vera L. ^{[2
]}

Ribeiro, Karina C. B. ^{[3
]}

Vassallo, Jos ^{[1
,4
]}

Soares, Fernando A. ^{[1
]}

机构：

[1] AC Camargo Canc Treatment & Res Ctr, Dept Pathol, Sao Paulo, Brazil

[2] Univ Sao Paulo, Fac Med, Dept Pathol, Sao Paulo, Brazil

[3] AC Camargo Canc Treatment & Res Ctr, Canc Registry, Sao Paulo, Brazil

[4] Univ Estadual Campinas, Lab Investigat & Mol Pathol, Sch Med, Sao Paulo, Brazil

来源：

MOLECULAR AND CELLULAR BIOCHEMISTRY | 2009年 / 321卷 / 1-2期

基金：

巴西圣保罗研究基金会;

关键词：

Classical Hodgkin lymphoma; Nitric oxide synthases; Apoptosis-related proteins; Epstein-Barr virus; Prognosis; EPSTEIN-BARR-VIRUS; STEMBERG CELLS; RETINOBLASTOMA PROTEIN; BCL-2; EXPRESSION; GENE-EXPRESSION; KAPPA-B; DISEASE; P53; PROLIFERATION; TRANSCRIPTION;

D O I：

10.1007/s11010-008-9923-1

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

Hodgkin and Reed-Sternberg (H-RS) cells of classical Hodgkin lymphoma (cHL) present an impaired expression of immunoglobulin genes, but escape apoptotic death. We investigated whether nitric oxide synthases (NOS) are expressed by H-RS cells, studied their association with EBV status and the expression of apoptotic proteins, and investigated their relationship to the clinical outcome of 171 patients. NOS1 and NOS2 were expressed in a large number of cases, whereas NOS3 expression was not detected. Positive associations were found between NOS1 and p53, bax and NOS2, bcl-2 and NOS2, bax and p53, and between bax and fasL. Inverse correlations were established between EBV and NOS2 and between EBV and bcl-2. A shorter overall survival (OS) was associated with strong expression of NOS2. In conclusion, NOS are expressed by H-RS cells of cHL.

引用

页码：95 / 102

页数：8

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