Temporal transcriptional response to ethylene gas drives growth hormone cross-regulation in Arabidopsis

被引：332

作者：

Chang, Katherine Noelani ^{[1
,2
]}

Zhong, Shan ^{[3
]}

Weirauch, Matthew T. ^{[4
,5
]}

Hon, Gary ^{[6
]}

Pelizzola, Mattia ^{[1
,2
]}

Li, Hai ^{[1
,2
]}

Huang, Shao-shan Carol ^{[1
,2
,7
]}

Schmitz, Robert J. ^{[1
,2
]}

Urich, Mark A. ^{[1
,2
]}

Kuo, Dwight ^{[8
]}

Nery, Joseph R. ^{[2
]}

Qiao, Hong ^{[1
,2
]}

Yang, Ally ^{[4
,5
]}

Jamali, Abdullah ^{[1
,2
]}

Chen, Huaming ^{[2
]}

Ideker, Trey ^{[9
,10
]}

Ren, Bing ^{[6
,11
]}

Bar-Joseph, Ziv ^{[3
,12
]}

Hughes, Timothy R. ^{[4
,5
]}

Ecker, Joseph R. ^{[1
,2
,7
]}

机构：

[1] Salk Inst Biol Studies, Plant Biol Lab, La Jolla, CA 92037 USA

[2] Salk Inst Biol Studies, Genom Anal Lab, La Jolla, CA 92037 USA

[3] Carnegie Mellon Univ, Sch Comp Sci, Lane Ctr Computat Biol, Pittsburgh, PA 15213 USA

[4] Univ Toronto, Dept Mol Genet, Toronto, ON M5S 1A1, Canada

[5] Univ Toronto, Banting & Best Dept Med Res, Toronto, ON M5S 1A1, Canada

[6] Univ Calif San Diego, Ludwig Inst Canc Res, La Jolla, CA 92093 USA

[7] Salk Inst Biol Studies, Howard Hughes Med Inst, La Jolla, CA 92037 USA

[8] Univ Calif San Diego, Inst Genom Med, Dept Med, Dept Bioengn, La Jolla, CA 92093 USA

[9] Univ Calif San Diego, Dept Med, San Diego, CA 92103 USA

[10] Univ Calif San Diego, Dept Bioengn, San Diego, CA 92103 USA

[11] Univ Calif San Diego, San Diego Sch Med, Dept Cellular & Mol Med, San Diego, CA 92103 USA

[12] Carnegie Mellon Univ, Sch Comp Sci, Machine Learning Dept, Pittsburgh, PA 15213 USA

来源：

ELIFE | 2013年 / 2卷

基金：

美国国家科学基金会; 加拿大健康研究院; 美国国家卫生研究院;

关键词：

CHIP-SEQ EXPERIMENTS; FACTOR-BINDING; TARGET GENES; DNA; MICROARRAYS; NETWORK; AUXIN; ETHYLENE-INSENSITIVE3; FEEDBACK; PATHWAYS;

D O I：

10.7554/eLife.00675

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The gaseous plant hormone ethylene regulates a multitude of growth and developmental processes. How the numerous growth control pathways are coordinated by the ethylene transcriptional response remains elusive. We characterized the dynamic ethylene transcriptional response by identifying targets of the master regulator of the ethylene signaling pathway, ETHYLENE INSENSITIVE3 (EIN3), using chromatin immunoprecipitation sequencing and transcript sequencing during a timecourse of ethylene treatment. Ethylene-induced transcription occurs in temporal waves regulated by EIN3, suggesting distinct layers of transcriptional control. EIN3 binding was found to modulate a multitude of downstream transcriptional cascades, including a major feedback regulatory circuitry of the ethylene signaling pathway, as well as integrating numerous connections between most of the hormone mediated growth response pathways. These findings provide direct evidence linking each of the major plant growth and development networks in novel ways.

引用

页数：20

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