Medicinal herb extract and a single-compound drug confer similar complex pharmacogenomic activities in MCF-7 cells

被引:5
作者
Yang, NS [1 ]
Shyur, LF
Chen, CH
Wang, SY
Tzeng, CM
机构
[1] Acad Sinica, U Vis Biotech Inc, Inst Bioagr Sci, Taipei, Taiwan
[2] U Vis Biotech Inc, Dept R&D, Taipei, Taiwan
[3] Natl Chiao Tung Univ, Dept Biol Sci & Technol, Hsinchu, Taiwan
关键词
Anoectochilus formosanus; MCF-7 cancer cells; pharmacogenomic activities; metabolite profiling;
D O I
10.1159/000077111
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Metabolite profiling and DNA microarray analysis of global gene expression profiles were employed to characterize the bioactivities of the herbal extract of Anoectochilus formosanus (AF), a popular folk medicine with anticancer activity, in MCF-7 cancer cells. The pharmacogenomic activities of this plant extract as a crude phytocompound mixture were compared to those conferred by the single-compound drug, plumbagin. A similar level of complexity in transcriptional regulation at the genomic level was observed for both AF extract- and plumbagin-treated MCF-7 cells, as revealed by the number of up- or downregulated genes as well as by the specific but distinct patterns found in the gene-clustering analysis. This finding offers evidence to support the search for fractionated medicinal herb extracts or phytocompound mixtures, in addition to single-compound drugs, as defined therapeutic agents. Copyright (C) 2004 National Science Council, ROC and S. Karger AG, Basel.
引用
收藏
页码:418 / 422
页数:5
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