Final results of a randomised trial comparing 'Tomudex'(R) (raltitrexed) with 5-fluorouracil plus leucovorin in advanced colorectal cancer

被引：199

作者：

Cunningham, D

Zalcberg, JR

Rath, U

Oliver, I

vanCutsem, E

Svensson, C

Seitz, JF

Harper, P

Kerr, D

PerezManga, G

机构：

[1] ROYAL MARSDEN HOSP, SUTTON, SURREY, ENGLAND

[2] HEIDELBERG REPATRIAT HOSP, HEIDELBERG, VIC, AUSTRALIA

[3] UNIV HEIDELBERG, MED KLIN, D-6900 HEIDELBERG, GERMANY

[4] ROYAL ADELAIDE HOSP, ADELAIDE, SA 5000, AUSTRALIA

[5] UZ GASTHUISBERG, LOUVAIN, BELGIUM

[6] SODER SJUKHUSET, S-10064 STOCKHOLM, SWEDEN

[7] GUYS HOSP, LONDON SE1 9RT, ENGLAND

[8] QUEEN ELIZABETH HOSP, BIRMINGHAM, AL USA

[9] HOSP GEN GREGORIO MARANON, MADRID, SPAIN

[10] NEWCASTLE MATER MISERICORDIASE HOSP, WARATAH, AUSTRALIA

[11] WESTERN HOSP, MELBOURNE, VIC, AUSTRALIA

[12] WESTMEAD HOSP, WESTMEAD, NSW 2145, AUSTRALIA

[13] BOX HILL HOSP, BOX HILL, VIC, AUSTRALIA

[14] ROYAL MELBOURNE HOSP, MELBOURNE, VIC, AUSTRALIA

[15] ST VINCENTS HOSP, SYDNEY, NSW 2010, AUSTRALIA

[16] AUSTIN HOSP, HEIDELBERG, VIC 3084, AUSTRALIA

[17] PETER MACCALLUM CANC INST, MELBOURNE, VIC 3000, AUSTRALIA

[18] ROYAL ADELAIDE HOSP, ADELAIDE, SA 5000, AUSTRALIA

[19] ROYAL PRINCE ALFRED HOSP, CAMPERDOWN 2050, NSW, AUSTRALIA

[20] PRINCESS ALEXANDRA HOSP, WOOLLOONGABBA, QLD 4102, AUSTRALIA

[21] HEIDELBERG REPATRIAT HOSP, HEIDELBERG, VIC, AUSTRALIA

[22] GRAZ UNIV, MED KLIN, A-8036 GRAZ, AUSTRIA

[23] INTERNE BRUGMANN HOSP, BRUSSELS, BELGIUM

[24] HOSP JOLIMONT, HAINE, BELGIUM

[25] UZ GASTHUISBERG, LOUVAIN, BELGIUM

[26] CHARLES UNIV, PRAGUE, CZECH REPUBLIC

[27] CENTRUM KLIN ONKOL, KUNZ, CZECH REPUBLIC

[28] CTR OSCAR LAMBERT, F-59020 LILLE, FRANCE

[29] FDN BERGONIE, F-33076 BORDEAUX, FRANCE

[30] CTR ANTOINE LACASSAGNE, F-06054 NICE, FRANCE

[31] CTR HENRI BECQUEREL, F-76038 ROUEN, FRANCE

[32] INST GUSTAVE ROUSSY, VILLEJUIF, FRANCE

[33] INST J PAOLI I CALMETTES, F-13009 MARSEILLE, FRANCE

[34] CHIRURG KLIN & POLIKLIN, MUNICH, GERMANY

[35] KRANKENHAUS NW FRANKFURT, FRANKFURT, GERMANY

[36] MED KLIN 1, ERLANGEN, GERMANY

[37] UNIV HEIDELBERG, MED KLIN, D-6900 HEIDELBERG, GERMANY

[38] ARZT INNERE MED, GOTTINGEN, GERMANY

[39] OSPED SAN GERARDO, MONZA, ITALY

[40] SAN CARLO BORROMEO HOSP, MILAN, ITALY

[41] OSPED CIVILE, BRESCIA, ITALY

[42] UNIV TRONDHEIM HOSP, TRONDHEIM, NORWAY

[43] NORWEGIAN RADIUM HOSP, OSLO, NORWAY

[44] UNIV TROMSO, TROMSO, NORWAY

[45] DR OFR CANDEIAS HOSP, OPORTO, PORTUGAL

[46] HOSP CAPUCHOS, LISBON, PORTUGAL

[47] PORTUGUES ONCOTOGIA LISBON, LISBON, PORTUGAL

[48] OSPED SAN GIOVANNI BELLINZONA, BELLINZONA, SWITZERLAND

[49] DR GD DELMORE KANTONSSPITAL, FRAUENFELD, SWITZERLAND

[50] NATL HOSP, BLOEMFONTEIN, SOUTH AFRICA

来源：

ANNALS OF ONCOLOGY | 1996年 / 7卷 / 09期

关键词：

chemotherapy; colorectal cancer; palliation; thymidylate synthase inhibitor; 'Tomudex';

D O I：

10.1093/oxfordjournals.annonc.a010800

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

[No abstract available]

引用

页码：961 / 965

页数：5

共 11 条

[1] THE EUROPEAN-ORGANIZATION-FOR-RESEARCH-AND-TREATMENT-OF-CANCER QLQ-C30 - A QUALITY-OF-LIFE INSTRUMENT FOR USE IN INTERNATIONAL CLINICAL-TRIALS IN ONCOLOGY [J].

AARONSON, NK ;

AHMEDZAI, S ;

BERGMAN, B ;

BULLINGER, M ;

CULL, A ;

DUEZ, NJ ;

FILIBERTI, A ;

FLECHTNER, H ;

FLEISHMAN, SB ;

DEHAES, JCJM ;

KAASA, S ;

KLEE, M ;

OSOBA, D ;

RAZAVI, D ;

ROFE, PB ;

SCHRAUB, S ;

SNEEUW, K ;

SULLIVAN, M ;

TAKEDA, F .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1993, 85 (05) :365-376

[2] 'Tomudex' (ZD1694): Results of a randomised trial in advanced colorectal cancer demonstrate efficacy and reduced mucositis and leucopenia [J].

Cunningham, D ;

Zalcberg, JR ;

Rath, U ;

Olver, I ;

VanCutsem, E ;

Svensson, C ;

Seitz, JF ;

Harper, P ;

Kerr, D ;

PerezManga, G ;

Azab, M ;

Seymour, L ;

Lowery, K ;

Ackland, SP ;

Basser, RL ;

Clarke, SJ ;

Goldstein, D ;

Green, MD ;

Grygiel, JJ ;

McKendrick, JJ ;

Millward, MJ ;

Olver, IN ;

Tattersall, MHN ;

Thomson, DB ;

Jakesz, R ;

Buset, M ;

Tueni, EA ;

VanCutsem, EJD ;

Bauer, J ;

Beska, F ;

Adenis, A ;

Brunet, R ;

Francois, E ;

Paillot, B ;

Rougier, P ;

Fink, UFW ;

Knuth, KRA ;

Koenig, HJ ;

Bohme, MWJ ;

Wander, HE ;

Amadori, D ;

Frassineti, L ;

Cocconi, G ;

Passalacqua, R ;

Frigerio, F ;

Barni, S ;

Luporini, G ;

Labianca, R ;

Marini, G ;

Zaniboni, A .

EUROPEAN JOURNAL OF CANCER, 1995, 31A (12) :1945-1954

[3]

ELLIOTT R, 1996, J ONCOL PHARM PRACT, V2, P186

[4] ASSESSMENT OF RESPONSE TO THERAPY IN ADVANCED BREAST-CANCER - PROJECT OF PROGRAM ON CLINICAL ONCOLOGY OF "INTERNATIONAL-UNION-AGAINST-CANCER, GENEVA, SWITZERLAND [J].

HAYWARD, JL ;

CARBONE, PP ;

HEUSON, JC ;

KUMAOKA, S ;

SEGALOFF, A ;

RUBENS, RD .

EUROPEAN JOURNAL OF CANCER, 1977, 13 (01) :89-94

[5]

HOLM S, 1979, SCAND J STAT, V6, P65

[6]

JACKMAN AL, 1991, CANCER RES, V51, P5579

[7] ANALYSIS OF REPEATED CATEGORICAL-DATA USING GENERALIZED ESTIMATING EQUATIONS [J].

LIPSITZ, SR ;

KIM, K ;

ZHAO, LP .

STATISTICS IN MEDICINE, 1994, 13 (11) :1149-1163

[8] Cost of treating advanced colorectal cancer: A retrospective comparison of treatment regimens [J].

Ross, P ;

Heron, J ;

Cunningham, D .

EUROPEAN JOURNAL OF CANCER, 1996, 32A :S13-S17

[9]

WITTES RE, 1989, MANUAL ONCOLOGIC THE

[10]

World Health Organization, 1979, WHO HDB REP RES CANC, V48, P1

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