A novel series of matrix metalloproteinase inhibitors for the treatment of inflammatory disorders

被引：41

作者：

Baxter, AD

Bird, J

Bhogal, R

Massil, T

Minton, KJ

Montana, J

Owen, DA

机构：

[1] Chiroscience Ltd., Cambridge Science Park, Cambridge CB4 4WE, Milton Road

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 07期

关键词：

D O I：

10.1016/S0960-894X(97)00125-X

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The preparation of a novel series of matrix metalloproteinase inhibitors is described, based on the use of a mercaptoacyl zinc binding moiety. The compounds have been tested in a model of rheumatoid arthritis and show good oral activity. (C) 1997 Elsevier Science Ltd.

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收藏

页码：897 / 902

页数：6

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